# Long term maternal and infant complications of pre-eclampsia

> **NIH NIH K01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2021 · $143,127

## Abstract

ABSTRACT
Pre-eclampsia is one of the most common complications of pregnancy and is associated with increased
morbidity and mortality for the infant and mother with the potential for long term implications. Health disparities
in incidence and outcomes of pre-eclampsia have been reported by some studies, further complicating the
condition. South Carolina (SC) has a large minority population (27.9% African-American; 5.3% Hispanic), and
more than 2/3 of resident births are among black women and other races/ethnicities. Although some evidence
exists related to poor maternal and infant complications of pre-eclampsia, potential racial differences in pre-
eclampsia associated morbidity and mortality have not been examined. SC provides a unique opportunity to
study racial differences, which is critical in terms of the risk, clinical course, and outcomes of pre-eclampsia.
The proposed project will be accomplished through two specific aims: (1) To determine the impact of pre-
eclampsia on long term maternal risk of cardiovascular disease at 1, 3, 5, and 10-years at the population level
in SC and to examine potential differences by race; and (2) To determine the impact of pre-eclampsia on risk
of poor birth and long term offspring outcomes at birth, 1, 3, 5, and 10-years at the population level in SC and
to examine potential differences by race. A retrospective cohort study will be conducted to investigate pre-
eclampsia as a risk factor for poor and long term maternal and infant outcomes using existing statewide data
for all live births that has been linked to birth certificates, maternal inpatient hospital discharge and emergency
department visit encounters, and mortality over a 13-year period (2004-2016). Dr. Malek is an epidemiologist
in the Department of Public Health Sciences at the Medical University of South Carolina. Her long-term career
development goal is to become an independent investigator whose research will contribute to improved health
for women, infants, and children; specifically through reduction of risk factors for poor infant as well as long
term offspring and maternal clinical outcomes. To help facilitate her transition into an independently funded
scientist, Dr. Malek will receive training in perinatal epidemiology, health disparities, and big data analysis. The
environment involves a multidisciplinary research team of epidemiologists (perinatal and cardiovascular), a
bioinformatician, and clinicians (obstetrics/gynecology, neonatology, and stroke neurology) invested in Dr.
Malek’s career development and success with a proven track record in mentorship, to ensure successful
completion of the proposed project. Moreover, preliminary results from this study will be used for preparation
of an NIH R01 grant proposal to facilitate enrolling a prospective cohort of women to obtain better data in terms
of pre-eclampsia risk factors, biological samples and physiologic measures, environmental risk factors, and
short and long term clinical outco...

## Key facts

- **NIH application ID:** 10229543
- **Project number:** 5K01HL138273-04
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Angela M Malek
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $143,127
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10229543

## Citation

> US National Institutes of Health, RePORTER application 10229543, Long term maternal and infant complications of pre-eclampsia (5K01HL138273-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10229543. Licensed CC0.

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