# Core Support for Cancer Center

> **NIH NIH P30** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $236,823

## Abstract

PROJECT SUMMARY - OVERALL
This is an application for years 46-50 funding of the Albert Einstein Cancer Center (AECC) CCSG to support
basic, translational, clinical, and population based research that addresses the causes, prevention and
treatment of cancer. In September 2015, ownership of the Albert Einstein College of Medicine transferred from
Yeshiva University to Montefiore Medicine. The AECC and its clinical partner, the Montefiore Health System,
now both under the Montefiore Medicine umbrella, are the major providers of cancer care and prevention
programs to the largely minority, and socioeconomically challenged, 1.4M residents of the Bronx. There are
five established AECC programs: The Tumor Microenvironment and Metastasis Program which brings together
advanced in in vivo imaging technologies and innovative mouse models focused on breast cancer, with recent
extension to other neoplasms, and translation into diagnostic, correlative and therapeutic studies in humans.
The Stem Cells, Differentiation and Cancer Program encompasses three interrelated themes - stem cell
biology, hematological malignancies, and a component focused on basic investigations on epigenetics/
transcription mechanisms and chromatin biology. The Experimental Therapeutics Program is the home for the
conduct of all clinical therapeutic trials, and the translation of basic discoveries into investigator-initiated clinical
initiatives, at AECC. The program is also the focal point for the development of small molecule inhibitors, and
novel immuno-therapeutics, for the treatment of cancer. The Cancer Epidemiology, Prevention and Control
Program, evolved from the prior Cancer Epidemiology Program, reflecting the expanded scope of population-
based research that encompasses infectious, metabolic, endocrine, obesity-related and genetic/epigenetic
causes of cancer and their prevention and control. The Biology of Colon Cancer Program focuses on the
convergence of dietary and genetic factors, along with the role of aging, in the pathogenesis of colorectal
cancer using mouse models of human cancer now encompassing studies on intestinal stem cells, the
microbiome and the villus niche with the objective of translating preclinical findings into prevention strategies.
There is research directed to the Bronx catchment area in all five AECC research programs, now brought
together with the inauguration of the Community Outreach and Engagement component and units within the
Montefiore organization, that provide well-established, effective surveillance, education and outreach
capabilities. This, along with the strong clinical electronic informatics at Montefiore and AECC, provide the
tools and support that expand the Center's research and implementation capabilities directed to the Bronx
population. There are twelve shared resources, including the recent addition of a Chemical Synthesis Shared
Resource, that support the spectrum of AECC research activities. There are currently 144 AECC members
...

## Key facts

- **NIH application ID:** 10229945
- **Project number:** 3P30CA013330-48S1
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** EDWARD CHU
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $236,823
- **Award type:** 3
- **Project period:** 1997-06-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10229945

## Citation

> US National Institutes of Health, RePORTER application 10229945, Core Support for Cancer Center (3P30CA013330-48S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10229945. Licensed CC0.

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