# Administrative Core

> **NIH NIH U54** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2020 · $25,644

## Abstract

PROJECT SUMMARY – Administrative Core
Children with NUP98-rearranged acute leukemias demonstrate a poor response to conventional therapy and
are associated a high rate of relapsed disease and poor outcome. These fusions account for approximately
10% of children with AML, yet our overall understanding of the molecular consequences of fusion oncoprotein
expression has been limited in part by a paucity of suitable model systems, which in turn has prevented the
development of rational and targeted therapeutic approaches. The overarching goals of the FusOnC2 Center
for Experimental and Preclinical Modeling of NUP98 Acute Leukemia are to understand the mechanistic basis
of leukemogenesis and develop and translate new, more effective therapeutic approaches for this form of
leukemia. These goals are to be accomplished in four research projects utilizing three core facilities,
Administrative, Genome Editing and Chemical Biology in four academic research centers: St Jude Children’s
Research Hospital, Memorial Sloan Kettering Cancer Center, Dana Farber Cancer Institute, and City of Hope.
The projects will perform experimental modeling of NUP98 and concomitant genomic lesions in mouse and
human models and test activity of chemical agents (Project 1); examine the role of NUP98 fusions on
transcriptional and chromatin complex assembly (Project 2); examine the role of phase separation in
transcriptional deregulation in leukemogenesis (Project 3); and develop and test new small molecule and
degrader therapeutic approaches (Project 4). The Center will be highly interactive and collaborative, with
interactions between projects and cores synergizing to accelerate the pace of discovery and translation for
this high risk form of leukemia. The Administrative Core will be located at St Jude and comprise an Executive
Management Team, administrative, grants and project management assistance. The Administrative Core will
facilitate administrative support for progress meetings, on site and FusOnC2 meetings, financial
management, internal and external data sharing and website, ensure compliance with all institutional, state
and federal regulations, and coordinate periodic reporting of research activity to the NIH.

## Key facts

- **NIH application ID:** 10230524
- **Project number:** 3U54CA243124-01S2
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Charles G Mullighan
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $25,644
- **Award type:** 3
- **Project period:** 2019-09-19 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10230524

## Citation

> US National Institutes of Health, RePORTER application 10230524, Administrative Core (3U54CA243124-01S2). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10230524. Licensed CC0.

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