Project Summary Therapies that can promote tissue repair and regeneration will have immense impact on human and animal health. Healthcare costs due to impaired tissue repair and regeneration following injury are a significant global burden, and are projected to be in the tens of billions by 2023 [1]. The healthcare system is faced with ever increasing numbers of non-healing chronic wounds, common in the elderly and in people with diabetes, as well as other forms of impaired healing, such as scarring and fibrosis following traumatic injury. Scarring and fibrosis can affect all organ systems including the skin, heart, lungs, liver and kidneys, and is common young, otherwise healthy individuals. These types of pathological, dysregulated repair responses in the body affect millions of people each year and demonstrate the critical need for new treatments and therapies to facilitate tissue repair and regeneration. Therefore it is imperative that we understand the molecular and cellular mechanisms that control repair and regeneration in vivo, and uncover the reasons why some organisms can regenerate while others cannot. This is key in progressing regenerative medicine to a new level. Advances in regenerative medicine occur through innovative research, and also through the rapid dissemination of breakthroughs in this field through fostering communication and collaboration in the scientific community. The Gordon Research Conference on Tissue Repair and Regeneration (GRC-TRR) has played an absolutely critical role in providing a forum for communicating the latest discoveries and innovations for the past three decades. The main objective of this conference is to bring together the top academic researchers with clinicians, early career scientists and senior PIs, in order to spark and facilitate new ideas and to generate new collaborations that will drive new discoveries and novel therapies in regenerative medicine. Specifically, we have planned nine scientific sessions, ranging from basic science involving insights from model organisms and mathematical modelling, to the more applied and clinical aspects, such as tissue engineering, the role of inflammation in tissue destruction and healing, as well as the latest approaches in clinical treatments. This will bring novel insights into how we can precisely manipulate tissues and organs in patients with developmental defects or injuries to provide a regenerative outcome. The 2021 GRC-TRR, which convenes every other year, will be the 15th meeting of this successful conference series. Programs for all of the past meetings can be found at the GRC website.