# Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides

> **NIH NIH K99** · STANFORD UNIVERSITY · 2020 · $81,105

## Abstract

Project Summary
This project is a supplement to the K99 grant “Alcohol-induced sleep disturbances and circuit dynamics of
arousal neuropeptides.” The applicant is requesting supplemental funding for an extension of the K99 award to
provide additional time to complete the proposed research studies and transition to an independent faculty
position, both of which have been delayed by the SarsCov2/Covid19 coronavirus pandemic.
 Further research is required to advance scientific knowledge of the intricate neurobiology underlying the
relationship between excessive alcohol drinking and deficits in sleep, a fundamental component of life. This
proposal will integrate in vivo measurements of neural calcium activity with electroencephalogram sleep
recordings in mouse models of long-term, free-choice intermittent heavy alcohol exposure, in order to establish
(or refute) causal relationships between the extended amygdala corticotropin-releasing factor system and
stress-like states of hyperarousal (disrupted sleep) during alcohol withdrawal. Knowledge gained from the
proposed experiments will inform future strategies for mitigation of drug abuse and relapse.

## Key facts

- **NIH application ID:** 10230900
- **Project number:** 3K99AA025677-02S1
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** William J Giardino
- **Activity code:** K99 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $81,105
- **Award type:** 3
- **Project period:** 2018-09-15 → 2021-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10230900

## Citation

> US National Institutes of Health, RePORTER application 10230900, Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides (3K99AA025677-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10230900. Licensed CC0.

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