# Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)

> **NIH NIH U54** · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $917,993

## Abstract

Overall Project Summary
In this application we establish the Maryland Polycystic Kidney Disease (PKD) Research and Translation Core
Center (MPKD-RTCC). The mission of this Center is to facilitate translational and basic research in the field of
polycystic kidney disease and related disciplines by providing unique resources, reagents and expertise to a
broad base of investigators. This proposal capitalizes on a long tradition of PKD research by MPKD-RTCC
investigators who have been at the forefront of PKD science for the past two decades. The Center consists of
4 highly collaborative and integrated biomedical research cores that together will distribute an essential
“toolbox” of reagents and expertise tailored specifically to PKD research. The MPKD-RTCC cores include 1)
Antibody and Vector 2) Mouse Models and Biobank 3) Cell Culture and Engineering and 4) Clinical and
Translation. Each core addresses a critical need in the PKD research pipeline, stretching from basic to clinical
investigation. In addition, MPKD-RTCC core leaders will pioneer solutions to perceived needs among PKD
Researchers by expanding in innovative directions. We expect that this strategy will continue our proven track
record of supporting high impact science across the country. These activities will be organized by an
Administrative Core led by two experienced investigators who will leverage the resources of two outstanding
research institutions in Baltimore, the University of Maryland Baltimore (UMB) and the Johns Hopkins School
of Medicine. As a team they will drive the MPKD-RTCC’s fundamental commitment to the principle of
collaborative science by streamlining SOPs for sharing high quality reagents and expertise, by integrating our
the core’s activities and by coordinating collaboration with other RTCCs within the PKD Research Consortium.
The Center’s Specific Aims are: 1) To provide critical state of the art reagents and expertise to a national group
of PKD investigators 2) To provide critical state of the art reagents and expertise to non-PKD investigators in
order to remove barriers to PKD related research 3) To develop innovative reagents and resources that will
advance biomedical discoveries in the field of PKD 4) To drive collaboration between MPKD-RTCC Cores and
other RTCCs within the PKD Research Consortium and 5) To partner with other RTCCs, the consortium
steering committee including the NIDDK to achieve the overall goals of the PKD Research Consortium.
Through expanded interdisciplinary collaborations, we hope to catalyze the translation of biomedical
discoveries that will prevent progression of polycystic kidney disease and its consequences.

## Key facts

- **NIH application ID:** 10231255
- **Project number:** 5U54DK126114-02
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Terry J Watnick
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $917,993
- **Award type:** 5
- **Project period:** 2020-08-24 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10231255

## Citation

> US National Institutes of Health, RePORTER application 10231255, Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC) (5U54DK126114-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10231255. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*