# Mouse Model and Biobank Core (MMBC)

> **NIH NIH U54** · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $204,127

## Abstract

Project Summary
Over the last decade mouse models have become a mainstay of translational polycystic kidney disease (PKD)
research and vital to investigators around the world. Mouse models have been used to establish the molecular
and cellular basis of PKD, to identify therapeutic targets and to validate treatment targets in vivo. The overarching
goal of the Mouse Models and Biobank Core (MMBC) is to dismantle barriers for investigators seeking to use
PKD mouse models in their research. The MMBC will facilitate PKD research by distributing and maintaining
PKD mouse models and reagents, by sharing expertise and by performing and/or providing assistance with
preclinical trials in mice using standardized protocols. In addition, the MMBC will develop innovative mouse
models that can be used to understand disease pathogenesis and to test new classes of therapeutic agents. To
achieve these goals we propose the following aims: 1) Provide the research community with a genetically
engineered live mouse bio-resource 2) Generate and maintain a repository of murine biospecimens 3) Assist in
preclinical testing of promising candidate therapies using appropriate PKD models 4) Provide personalized
consultation and tools for investigators who use PKD mouse models in their research and 5) Generate and
distribute a novel Pkd2 mouse model that can be used for pre-clinical testing of agents that target defective
channel processing and/or function. In summary, completion of these aims will allow the Mouse Models and
Biobank Core to assist a diverse community of investigators in conducting high quality research using state-of-
the-art mouse models thereby accelerating discovery in the field of polycystic kidney disease.

## Key facts

- **NIH application ID:** 10231258
- **Project number:** 5U54DK126114-02
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Patricia Outeda Garcia
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $204,127
- **Award type:** 5
- **Project period:** 2020-08-24 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10231258

## Citation

> US National Institutes of Health, RePORTER application 10231258, Mouse Model and Biobank Core (MMBC) (5U54DK126114-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10231258. Licensed CC0.

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