# “Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $871,099

## Abstract

PROJECT SUMMARY
The prenatal period is regarded as one of the most sensitive phases in human development. Events that occur
during gestation can alter the course of development with lasting impact. Presently, the COVID-19 pandemic is
exerting wide-spread impact on the lives of expectant mothers around the world. Particularly salient pandemic-
related stressors that are being experienced by pregnant women are social isolation and uncertainty stress.
There is ample physiological and behavioral literature showing that social isolation and uncertainty stress affect
typical human and animal psychobiological functioning, but there is an absence of knowledge about how these
conditions might impact the physical and psychological health of a pregnant woman, and what the
consequences of those changes might be for her developing child. The central objective of this proposal is to
build foundational knowledge about the effects of prenatal social isolation and uncertainty stress on maternal
psychobiology and infant neurobehavior. We will explore several candidate physiological systems in the
mother to elucidate mechanisms that underlie associations between maternal stressors and child outcomes.
To achieve these goals, we will recruit 200 women from a large New York City cohort established at the height
of the pandemic into a prospective, longitudinal study that will include pre- and postnatal biospecimen
collection and child neurobehavioral assessments at 6-, 12- and 24 months. Multi-modal neuroimaging
strategies, including infant EEG and quantitative MRI, and innovative remote biophysical data collection
strategies will be employed. The primary aims of this project are to (i) examine the impact of prenatal social
isolation and uncertainty stress on maternal biology and postnatal mental health; (ii) evaluate the influence of
maternal prenatal social isolation and uncertainty stress on infant neurobehavioral development; and (iii)
examine the role of prenatal social isolation and uncertainty stress on mother-infant bi-directional interactions.
We will thus be able to meaningfully evaluate whether, and how, prenatal social isolation and uncertainty
stress modify maternal biology and affect, and the neurobehavioral consequences of those impacts on infants.
Such work would constitute a substantial advance in our understanding of the longitudinal effects of prenatal
psychosocial stress exposures, the underlying mechanistic pathways, and the origins of child neurobehavioral
disorders.

## Key facts

- **NIH application ID:** 10231690
- **Project number:** 1R01MH126468-01
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Natalie Hiromi Brito
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $871,099
- **Award type:** 1
- **Project period:** 2021-05-15 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10231690

## Citation

> US National Institutes of Health, RePORTER application 10231690, “Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment (1R01MH126468-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10231690. Licensed CC0.

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