# Clinical Pharmacology Shared Resource

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2021 · $123,283

## Abstract

Clinical Pharmacology Shared Resource – Project Summary 
Established as a University of Kansas Cancer Center (KUCC) developing shared resource in 2012 and 
selected as an established shared resource in 2015, the Clinical Pharmacology Shared Resource (CPSR) is 
led by Gregory Reed, PhD. This shared resource has three functional components. 
1. Correlative Laboratories - directed by LaToya Berry. The Correlative Laboratories provide GXP-compliant 
 acquisition, processing and storage or shipping of clinical research samples. Following either a sponsor's 
 protocol or CPSR protocols, the staff efficiently and precisely prepares samples from blood (whole blood, 
 serum, plasma or specific blood cell fractions), urine and saliva or processes tissue samples, and then 
 stores or transfers those samples for analysis. The Correlative Laboratories are located near patient 
 treatment areas at the KU Clinical Research Center (KU CRC), Westwood (The University of Kansas 
 Health System's outpatient clinical facility) and at The University of Kansas Health System's main campus. 
 The Correlative Laboratories also provide scientific and technical support to the community oncology sites 
 and Midwest Cancer Alliance (MCA) sites to assist them in sample acquisition, processing and shipping. 
2. Bioanalytical Laboratory - led by Reed. Located at the KU CRC, this GLP-compliant facility prepares 
 biological fluids, cells or tissue samples, and analyzes them for concentrations of drugs, drug metabolites 
 and other small molecule biomarkers. Analyses are performed on two UPLC-tandem quadrupole mass 
 spectrometers, with a combined sample throughput of over 30,000 samples per year. 
3. Pharmacokinetics/Pharmacodynamics (PK/PD) Unit – also directed by Reed. Reed performs calculations 
 and modeling using the Phoenix/WinNonlin® software to define and interpret the kinetics of drugs and their 
actions. 
In addition to these study-specific activities, the staff of the CPSR also play a major role in educating future 
physicians and researchers, as well as nurses and study coordinators currently involved in cancer clinical 
trials, on the theory and practice of clinical pharmacology and on how those applications of clinical 
pharmacology result in more powerful and informative results from clinical trials.

## Key facts

- **NIH application ID:** 10232197
- **Project number:** 5P30CA168524-10
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** Paul Toren
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $123,283
- **Award type:** 5
- **Project period:** 2012-07-11 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10232197

## Citation

> US National Institutes of Health, RePORTER application 10232197, Clinical Pharmacology Shared Resource (5P30CA168524-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10232197. Licensed CC0.

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