# Lead Development & Optimization Shared Resource

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2021 · $129,670

## Abstract

Lead Development and Optimization Shared Resource – Project Summary 
The Lead Development and Optimization Shared Resource (LDOSR) is a University of Kansas Cancer Center 
(KUCC) shared resource composed of three functions: 1) High Throughput Screening (HTS); 2) Medicinal 
Chemistry (MC); and 3) the Biotechnology, Innovation and Optimization Center (BIOC). Collectively, these 
three functions allow the LDOSR to accelerate projects from early method development around cancer 
pathways or targets, through high throughput screening, compound hit prioritization, secondary in vitro 
confirmatory assays, medicinal chemistry optimization, in vitro pharmacology testing, in vivo pharmacokinetics 
and drug delivery formulations for in vivo preclinical proof-of-concept testing. 
The LDOSR has modified its composition and activities over the past four years in order to provide the best 
possible support to KUCC members. The Preclinical Proof of Concept (PPOC) service was eliminated from the 
LDOSR at the end of 2012 because many KUCC members had similar functionality within their own 
laboratories. Furthermore, it was realized that the LDOSR would be enhanced by a dedicated medicinal 
chemistry expert. Therefore, Frank Schoenen joined the LDOSR to provide medicinal chemistry optimization 
services. 
In 2014, the LDOSR formed a project management service known as the Target Acceleration Group (TAG). 
TAG aims to accelerate projects from early method development around cancer pathways or targets and more 
seamlessly move projects between HTS, Medicinal Chemistry and the BIOC. TAG helps KUCC members 
navigate the drug discovery, delivery and development process more efficiently.

## Key facts

- **NIH application ID:** 10232198
- **Project number:** 5P30CA168524-10
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** Amanda Elizabeth Brinker
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $129,670
- **Award type:** 5
- **Project period:** 2012-07-11 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10232198

## Citation

> US National Institutes of Health, RePORTER application 10232198, Lead Development & Optimization Shared Resource (5P30CA168524-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10232198. Licensed CC0.

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