# Transgenic & Gene-Targeting Shared Resource

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2021 · $98,250

## Abstract

Transgenic and Gene-Targeting Shared Resource – Project Summary
Genetically altered mouse models are important tools for the researchers at the University of Kansas Cancer
Center (KUCC). The production and analysis of such models ultimately leads to a better understanding of the
nature, progression and functional genomics of tumor formation. They also serve as in vivo models for
diagnostics and treatment. The Transgenic and Gene-Targeting shared resource (TGTSR), led Jay L. Vivian
PhD, supports members of KUCC by providing centralized and comprehensive technical services for the
production of novel transgenic and gene-targeted rodents and genetically altered pluripotent stem cells. The
TGTSR uses cutting edge methods, state-of-the-art instrumentation, and novel reagents for the generation of
these models. The TGTSR, housed at the KUMC campus, has four full time technical staff along with Vivian.
The Cancer Center support of the TGTSR allows for the development of specific initiatives in the Facility
relevant to cancer research. For example, certain transgenic methods and mutations are particularly relevant
to cancer studies, including tissue specific transgene expression, subtle mutations that recapitulate clinically
identified variants and somatic mutations and strain-specific nuclear transfer. Emerging technologies, including
in vivo genome editing methods (e.g. CRISPR/Cas9 and TALE nucleases) are providing a more rapid means
of generating these types of novel mouse models of tumor progression. The integration of these continually
evolving methods into the `toolbox' of the TGTSR greatly accelerates the development of animal models of
cancer, while also reducing costs to KUCC researchers on all campuses.

## Key facts

- **NIH application ID:** 10232199
- **Project number:** 5P30CA168524-10
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** JAY L VIVIAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $98,250
- **Award type:** 5
- **Project period:** 2012-07-11 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10232199

## Citation

> US National Institutes of Health, RePORTER application 10232199, Transgenic & Gene-Targeting Shared Resource (5P30CA168524-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10232199. Licensed CC0.

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