# Core C - Bioinformatics and Genomics Core

> **NIH NIH P01** · WICHITA STATE UNIVERSITY · 2021 · $119,306

## Abstract

Project Abstract
The Bioinformatics and Genomics Core (Core C) will support the scientific investigations of Projects 1-3
by assisting with the analysis of glycan mass spectrometry (MS) and next-generation sequencing (NGS)
data. Projects 2 and 3 have both proposed the use of NGS as a tool for investigating the transcriptome-
level differences between samples. NGS experiments have the capacity to generate large volumes of
data with specialized data analysis and storage requirements. Core C will provide support to all the
research projects via the following specific aims: 1: Develop a glycomics database and a web
application server for storing, processing and analyzing oligosaccharide data from Mass
Spectrometry experiments. This will replace the Glycomics Database initiated at Wichita State,
transferred to the University of Kansas, and found to be lacking essential functions. The new database
will provide automated data entry, conversion of free-text based MS data tables into a searchable
relational database, and better tools for comparing glycan populations of glycoform preparations. 2:
Support the analysis of gene expression data generated from both in vitro and in vivo studies
using microarray or RNA-seq experiments. The Core will receive RNA samples from Projects 2 and 3,
oversee library construction and sequencing and carry out bioinformatics data analyses to identify
differentially expressed genes. 3: Comparison and functional characterization of the gene
expression patterns from the in vitro and in vivo studies. Differentially expressed genes between
samples will be further analyzed to relate the functional significance of these genes with cellular
pathways and regulatory networks associated with ovarian senescence.

## Key facts

- **NIH application ID:** 10232320
- **Project number:** 5P01AG029531-10
- **Recipient organization:** WICHITA STATE UNIVERSITY
- **Principal Investigator:** CHITTIBABU GUDA
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $119,306
- **Award type:** 5
- **Project period:** 2009-04-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10232320

## Citation

> US National Institutes of Health, RePORTER application 10232320, Core C - Bioinformatics and Genomics Core (5P01AG029531-10). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10232320. Licensed CC0.

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