# Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue Mapping

> **NIH NIH U54** · VANDERBILT UNIVERSITY · 2020 · $100,000

## Abstract

PROJECT SUMMARY - Supplement
This application proposes the purchase of a nanoString GeoMx Digital Spatial Profiler to enable
spatial transcriptomics to be integrated into the characterization pipeline of the BIOmolecular
Multimodal Imaging Center (BIOMIC) at Vanderbilt University, a Tissue Mapping Center
associated with the Human BioMolecular Atlas Program (HuBMAP). The mission of BIOMIC is
to establish a platform of integrated technologies for the comprehensive molecular imaging and
construction of 3-dimensional (3-D) molecular atlases of human kidney tissues. As a member of
the HuBMAP consortium, we aim to develop methods and assays that can be easily integrated
with technologies implemented by all consortium members. To this end, we propose the
introduction of a spatial transcriptomics workflow into our multimodal imaging pipeline. This will
allow us to make spatial connections with a wider range of molecular classes including
metabolomics (IMS), lipidomics (IMS), proteomics (IMS/LC), cell typing (CODEX), and gene
expression (proposed here). Ultimately, this combination of technologies will provide an
unprecedented ability to define deep and wholistic molecular profiles for specific cell types and
tissue functional units in human organs. Moreover, the inclusion of spatial transcriptomics into
our analysis pipeline will allow for greater integration of our molecular information with data
produced by other consortium member, particularly those focusing on sequencing efforts.

## Key facts

- **NIH application ID:** 10232491
- **Project number:** 3U54DK120058-03S1
- **Recipient organization:** VANDERBILT UNIVERSITY
- **Principal Investigator:** RICHARD M CAPRIOLI
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $100,000
- **Award type:** 3
- **Project period:** 2020-09-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10232491

## Citation

> US National Institutes of Health, RePORTER application 10232491, Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue Mapping (3U54DK120058-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10232491. Licensed CC0.

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