# Improving Opioid Use Disorder Treatment for Hospitalized Patients with Endocarditis

> **NIH NIH F32** · UNIVERSITY OF PENNSYLVANIA · 2021 · $68,310

## Abstract

PROJECT SUMMARY/ABSTRACT
Patients hospitalized for opioid use disorder-associated infective endocarditis (OUD-IE) have distinctly poor
outcomes and high costs. Despite the availably of effective treatment for opioid use disorder and the opportunity
to intervene during hospitalization, health care staff tend not to address opioid use disorder during hospitalization
for OUD-IE. Existing models of hospital care for patients with opioid use disorder can inform hospital care delivery
for OUD-IE patients, though significant adaptation of these models is needed to meet the unique needs of OUD-
IE patients related to their prolonged hospital stays. Little is known regarding how to best deploy evidence-based
opioid use disorder interventions for medically hospitalized patients. The aims of the proposed study are to: 1)
Characterize current practices of health care staff regarding hospital care delivery for OUD-IE patients; 2)
Examine the appropriateness, feasibility, and acceptability of implementing evidence-based opioid use disorder
care for hospitalized OUD-IE patients; and 3) Adapt an intervention for hospitalized OUD-IE patients and develop
a corresponding toolkit of implementation strategies. To accomplish these aims, I will engage health care staff
who care for OUD-IE patients at the Hospital of the University of Pennsylvania and will rely on mentorship and
collaborators from faculty in the University of Pennsylvania's Schools of Nursing and Medicine. Qualitative data,
in conjunction with expert opinion, will be integrated to inform an adapted opioid use disorder intervention for
OUD-IE patients and a corresponding toolkit of implementation strategies. Findings from this study will increase
the currently limited efficacy of care delivery for hospitalized patients with opioid use disorder and ultimately
enhance their outcomes. This program of research and corresponding training activities will facilitate the
applicant's long-term goal of pursuing an academic research career committed to improving the quality of care
and outcomes for hospitalized people with substance use disorders through implementation science. Specific
training goals are to: 1) Understand current practices for care delivery for hospitalized patients with OUD; 2)
Acquire a strong foundation in methods for the proposed project and for future research; 3) Develop skills related
to designing and implementing new practices in hospitals; and 4) Integrate professional development, grant
writing, and scholarship to prepare to be an independent researcher.

## Key facts

- **NIH application ID:** 10233082
- **Project number:** 1F32DA053763-01
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Rachel Elizabeth French
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $68,310
- **Award type:** 1
- **Project period:** 2021-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10233082

## Citation

> US National Institutes of Health, RePORTER application 10233082, Improving Opioid Use Disorder Treatment for Hospitalized Patients with Endocarditis (1F32DA053763-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10233082. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*