# Project 2 - TB Translation as a Target

> **NIH NIH P01** · TEXAS A&M AGRILIFE RESEARCH · 2020 · $504,514

## Abstract

Translation plays a key role in the survival of any cell and is a hub for many regulatory pathways that
control cellular growth. Due to this complexity, the ribosome has proven to be a vulnerable antibiotic
target and several existing antituberculous compounds block translation. We have capitalized on recent
advances in cryo-EM techniques to explore the unique structural aspects of the mycobacterial ribosome
that might alter antimicrobial efficacy and be exploited by new therapeutics.

## Key facts

- **NIH application ID:** 10233090
- **Project number:** 5P01AI095208-07
- **Recipient organization:** TEXAS A&M AGRILIFE RESEARCH
- **Principal Investigator:** JAMES C SACCHETTINI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $504,514
- **Award type:** 5
- **Project period:** 2012-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10233090

## Citation

> US National Institutes of Health, RePORTER application 10233090, Project 2 - TB Translation as a Target (5P01AI095208-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10233090. Licensed CC0.

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