# Efficacy Study of Cisplatin Beads

> **NIH FDA R01** · ROYER BIOMEDICAL, INC. · 2021 · $86,071

## Abstract

Project Summary-Field Efficacy Study of Cisplatin Beads for the Treatment
of Sarcoid in Horses
The objective of this study is to determine the efficacy of treatment for
cutaneous sarcoids in horses with cisplatin impregnated, slow release beads.
Ten horses, client-owned, with spontaneously developing cutaneous sarcoids
of < 3 cm diameter will be utilized. Gender, age, reproductive status and breed
will be documented in the study. Horses will be examined prior to bead
implantation to ensure that they are systemically healthy and there are no
comorbidities. This will be determined by physical examination, serum
chemistry analysis, complete blood cell count, and urinalysis with
GGT/creatinine ratio. On Day 0, the sarcoid will be surgically excised, and the
incision site will be implanted with up to 3 cisplatin- impregnated beads. The
tissue removed will be stored in 10% buffered formalin and submitted for
routine histopathological analysis. Horses will subsequently be monitored by
routine clinical assessment as deemed appropriate by the treating clinician for
the surgical site. At minimum, the surgical site will be reexamined at 10 days
and 180 days, and the site documented by photograph. More frequent
assessment may occur based upon clinical need. Success will be defined as
no recrudescence of the sarcoid at that location within 180 days in greater than
50% of the treated horses. This success criterion is based upon the reported
finding of a success rate of 30-50% of cases treated by surgical excision alone,
in which “most tumors recurred within 6 months”.

## Key facts

- **NIH application ID:** 10233929
- **Project number:** 1R01FD007246-01
- **Recipient organization:** ROYER BIOMEDICAL, INC.
- **Principal Investigator:** Tatiana Bizikova
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** FDA
- **Fiscal year:** 2021
- **Award amount:** $86,071
- **Award type:** 1
- **Project period:** 2020-12-01 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10233929

## Citation

> US National Institutes of Health, RePORTER application 10233929, Efficacy Study of Cisplatin Beads (1R01FD007246-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10233929. Licensed CC0.

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