# Coordinating Center for the Drug Induced Liver Injury Network (DILIN)

> **NIH NIH U24** · DUKE UNIVERSITY · 2021 · $1,407,155

## Abstract

Abstract
Liver injury due to prescription drug and non-prescription drugs or Herbal and Dietary supplement (HDS) is an
important medical, scientific, and public health problem in the United States. Drug-induced liver injury (DILI) is
the most common reason for non-approval, withdrawal, limitation in use, and clinical monitoring by the Food and
Drug Administration (FDA). The National Institute of Diabetes and Kidney Diseases (NIDDK) of the National
Institute of Health established the Drug Induced liver injury Network (DILIN) in 2003 and has proposed the
continuation of the DILIN. As described in the RFA, the DILIN will be a network composed of six Clinical Centers
(CCs) to identify and enroll patients eligible for DILIN and one Data Coordinating Center (DCC) to provide
managerial, logistic, and analytic functions for the DILIN. The future areas of the network study is to continue the
clinical, biochemical, histologic and biologic characterization of DILI, to lay groundwork for future studies of
treating severe DILI and to engage pharmacovigilance with information on DILI. The Duke Clinical Research
Institute (DCRI) proposes to continue as the DCC for the DILIN. In this role, we will apply our extensive
experience and research infrastructure to coordinate, support and facilitate the activities of the DILIN network.
In particular, we will attend to the following specific aims: (1) Support the analytic core with chemical analyses of
herbal and dietary supplements; (2) Provide statistical leadership to identify genetic and non-genetic biomarkers
for DILI and to design treatment trial to improve the natural history of DILI; (3) Support manuscript preparation
and ancillary studies; (4) Provide overall network coordination and logistics; (5) Ensure quality assurance and
continue data management activities; (6) Contribute to maintain LiverTox.

## Key facts

- **NIH application ID:** 10234166
- **Project number:** 5U24DK065176-19
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Huiman X Barnhart
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,407,155
- **Award type:** 5
- **Project period:** 2003-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10234166

## Citation

> US National Institutes of Health, RePORTER application 10234166, Coordinating Center for the Drug Induced Liver Injury Network (DILIN) (5U24DK065176-19). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10234166. Licensed CC0.

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