# UNC Center for AIDS Research Core E Clinical Pharmacology/Analytical Chemistry

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $455,525

## Abstract

PROJECT SUMMARY/ABSTRACT – CLINICAL PHARMACOLOGY AND ANALYTICAL
CHEMISTRY (CPAC) CORE (CORE E)
The overarching goal of the Clinical Pharmacology and Analytical Chemistry (CPAC) Core is to facilitate the
development of safe, effective strategies for HIV prevention, treatment and cure. To achieve this goal, the CPAC
Core provides pharmacology and bioanalytical expertise to advance research within and beyond the UNC CFAR
through the following specific aims: (1) provide services to expedite translation of HIV research into therapeutic
strategies, (2) introduce new services to respond to evolving HIV research needs, (3) interact within and beyond
the UNC CFAR to enhance HIV research collaborations, (4) support scientific working groups, research interest
groups, early stage investigators, and investigators new to HIV to develop the next generation of scientific
leadership, (5) prioritize dissemination/outreach, strategic planning, and evaluation to maximize impact, and (6)
follow standardized policies and procedures to promote harmonious intra-CFAR interaction. The CPAC Core
executes these aims by proactively engaging investigators to identify and deliver services essential for HIV
pharmacology research. The Core contributes to the design, management, analysis, and publication of HIV
research by assisting with hypothesis framing, study design, and grant/proposal development, by facilitating
multidisciplinary and translational approaches to clinical study design and conduct, and by selecting or
generating optimal bioanalytical or pharmacometric methods, with subsequent provision of analyses, in both
preclinical and clinical settings. New services are developed to respond to the evolving needs of the HIV research
community working within priority research areas as well as tailored to individual investigator requests. Early
stage investigators and investigators new to HIV research receive the highest priority for Core services. Strong
institutional support from the UNC Eshelman School of Pharmacy allows the Core to take full advantage of
existing infrastructure and resources, including contacts with faculty renowned for their expertise in specialized
fields of pharmacology. The Core Co-Directors, Drs. Angela Kashuba and Mackenzie Cottrell, are responsible
for Core management and strategic planning, in consultation with the Core’s Internal and External Advisory
Boards, as well as through surveys of the CFAR membership and discussions at CFAR retreats.

## Key facts

- **NIH application ID:** 10234697
- **Project number:** 2P30AI050410-24
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Angela D Kashuba
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $455,525
- **Award type:** 2
- **Project period:** 2001-08-20 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10234697

## Citation

> US National Institutes of Health, RePORTER application 10234697, UNC Center for AIDS Research Core E Clinical Pharmacology/Analytical Chemistry (2P30AI050410-24). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10234697. Licensed CC0.

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