# Hispanic Chronic Renal Insufficiency Cohort(CRIC) Study

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $671,033

## Abstract

Project Summary/Abstract
Despite the dramatic growth of the Hispanic population with end stage renal disease in the U.S., relatively little
is known about earlier stages of chronic kidney disease (CKD) in Hispanics. The Hispanic Chronic Renal
Insufficiency Cohort (CRIC) Study is based at the University of Illinois at Chicago and is an ancillary study to
the NIDDK-sponsored multi-center CRIC Study. During the first two funding periods, the study assembled a
sizable cohort of Hispanics with moderate to severe CKD and addressed critical questions. One key finding
was that compared to non-Hispanics whites, Hispanics with CKD are burdened by lower socioeconomic status,
poorer blood pressure control, higher depressive symptoms, and lower health-related quality of life (HRQOL).
Furthermore, we found that Hispanics with CKD experienced a twofold higher rate of CKD progression but this
disparity was explained by potentially modifiable sociodemographic and clinical factors. This finding has
important implications for practice and underscores the need to better understand factors influencing risk factor
control and health outcomes in Hispanics. As a result of our findings, the scientific scope of this competitive
renewal has been broadened to address knowledge gaps in the following areas: 1) epidemiology of mild CKD,
2) impact of sociocultural/ psychosocial factors on CKD progression and cardiovascular events among
Hispanics, and 3) influence of CKD progression on patient-centered outcomes. First, because individuals with
mild CKD comprise a much larger proportion of the CKD population, improving our understanding of modifiable
risk factors in early disease may have substantial public health implications. Recognizing the need to
understand the epidemiology of mild CKD, the parent CRIC Study recently recruited 1500 additional adults with
eGFR 45-70 ml/min/1.73m2. However, only 4% of these participants are Hispanic. Second, there is
accumulating evidence suggesting that sociocultural and psychosocial factors influence health outcomes in
Hispanics but these factors have not been studied in the context of CKD. Third, in addition to studying
traditional clinical outcomes, there is growing recognition of the need to study outcomes defined by patients as
being important. This application seeks to continue follow-up of the existing Hispanic CRIC cohort and enrich it
with recruitment of 125 Hispanics with mild CKD (eGFR 45-70 ml/min/1.73m2) to accomplish the following
Aims: 1) Evaluate the association of Hispanic ethnicity with risk of CKD progression and cardiovascular events
in adults with mild CKD; 2) Investigate the association of sociocultural and psychosocial factors with CKD
progression and cardiovascular events among Hispanics across the spectrum of CKD severity; and 3)
Examine the relationship of CKD progression with patient-centered outcomes (e.g., HRQOL, physical function,
pain) across the spectrum of CKD severity, among Hispanics and across racial/ethnic...

## Key facts

- **NIH application ID:** 10236348
- **Project number:** 5R01DK072231-15
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** JAMES P. LASH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $671,033
- **Award type:** 5
- **Project period:** 2005-09-20 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10236348

## Citation

> US National Institutes of Health, RePORTER application 10236348, Hispanic Chronic Renal Insufficiency Cohort(CRIC) Study (5R01DK072231-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10236348. Licensed CC0.

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