# Boston Biomedical Innovation Center

> **NIH NIH U54** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $1,760,250

## Abstract

A well-recognized gap exists in the path from biomedical discovery in academia to clinical
application and commercialization of therapeutic, device, and diagnostic technologies in
cardiovascular, pulmonary, hematologic, and sleep disorders. This chasm is the result of
inadequate funding for support of proof-of concept or validation studies essential for early stage
development; insufficient access to the resources and expertise needed to develop new
technologies; and a lack of knowledge and experience among academic investigators in bringing
new ideas to commercial realization. Within the partnering institutions included in this application,
the essential elements exist with which to build the infrastructure needed to support and sustain
the uninterrupted, durable flow of inventions from discovery through development and
commercialization. While these institutions have a clear track record of remarkably successful
development of many biomedical technologies, most of these commercial successes have been
achieved by the tenacity of individual inventors rather than with the help of committed institutional
mechanisms. We proposed to address these key shortcomings by establishing the regional
Boston Center for Accelerated Innovation in Therapeutics, Devices, and Diagnostics for Heart,
Lung, Blood, and Sleep Disorders (B-BIC, or the Boston Biomedical Innovation Center). The key
objectives of this Center. are to: 1) develop an integrated infrastructure that would expand the
universe of commercializable technologies for heart, lung, blood, and sleep disorders; 2) place
these opportunities in the proper evaluative context through an engagement ("seed it"), solicitation
("find it"), and selection ("pick it") strategy; 3) efficiently and effectively bring those selected to an
appropriate exit point from the development process; and 4) provide the educational and
mentoring infrastructure necessary for the development of the proper entrepreneurial skills among
academic innovators. By achieving these goals, B-BlC would change the culture of our academic
environment, as well as the relationship between the public and private sectors in facilitating
successful development strategies for technologies in heart, lung, blood, and sleep disorders for
the ultimate benefit of patients and society.

## Key facts

- **NIH application ID:** 10236857
- **Project number:** 3U54HL119145-07S1
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** DAVID E. GOLAN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,760,250
- **Award type:** 3
- **Project period:** 2020-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10236857

## Citation

> US National Institutes of Health, RePORTER application 10236857, Boston Biomedical Innovation Center (3U54HL119145-07S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10236857. Licensed CC0.

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