# Targeted Protein Degradation: From Small Molecules to Complex Organelles

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2021 · $16,800

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Targeted Protein Degradation: From Small
Molecules to Complex Organelles, organized by Drs. Sascha Martens, Tim Clausen and Judith Frydman. The
conference will be held in Vienna, Austria from June 6-9, 2021.
Targeted protein degradation plays a critical role in regulating nearly all cellular functions, and as such, its
dysfunction is associated with severe pathologies including diseases like cancer, neurodegeneration and age-
associated diseases. Therefore, fundamental insights into protein clearance pathways might be harnessed for
therapeutic applications against a wide range of diseases. While much progress has been made in revealing
mechanisms of autophagy and the ubiquitin-proteasome system, the major protein degradation pathways
defined thus far, these fields continue to remain isolated from each other despite the interconnection of these
processes. This separation is now leading to an urgent need to discuss the interplay of these pathways at the
molecular and cellular levels to integrate our understanding of these processes and how they contribute to
disease pathology. This conference will bring together researchers from these different fields, who do not
typically interact, to build a holistic and integrated vision of protein degradation. Such an integrative
conference highlighting the connections between the different branches of protein degradation research does
not yet exist, so this Keystone Symposia conference will be the first of its kind to reshape how these fields
interact and collaborate to yield transformative insights into both basic science and disease processes. Topics
of discussion will include: (1) Substrate recognition and processing by energy-dependent proteases, autophagy
and lysosomal pathways; (2) Signals targeting proteins to distinct degradation pathways; (3) Interplay between
proteolytic systems and chaperone pathways; (4) Reprogramming degradation with small molecules for
therapeutic applications; (5) Degradation programs driving global proteome remodeling. Attendees will be
exposed to novel perspectives, as well as methods, techniques and approaches, that will advance research
within their field, and across the many different components in the protein degradation landscape.

## Key facts

- **NIH application ID:** 10237082
- **Project number:** 1R13TR003730-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $16,800
- **Award type:** 1
- **Project period:** 2021-05-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10237082

## Citation

> US National Institutes of Health, RePORTER application 10237082, Targeted Protein Degradation: From Small Molecules to Complex Organelles (1R13TR003730-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10237082. Licensed CC0.

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