# Pathology Core

> **NIH NIH P01** · MAYO CLINIC ARIZONA · 2021 · $134,736

## Abstract

The Pathology Core (Dr. Cook) will provide thorough central pathology review of all patient samples studied in
Projects 1-4 of this grant, utilizing web-based e-pathology resources and providing additional ancillary testing
analyses when required to arrive at a consensus diagnosis. Tissue microarrays will also be constructed from
paraffin blocks for Projects 2 and 3, facilitating cost-efficient downstream analysis. Aim 1) To provide a system
for central pathology review utilizing digital slide imaging. Central review by a panel of internationally
recognized lymphoma experts has been one of the cornerstones of prior LLMPP studies. Each case is
reviewed by four lymphoma pathology experts, and agreement by at least three pathologists defines a
consensus diagnosis. For cases where an initial consensus is not reached, the cases are reviewed by the
entire pathology committee together and a consensus diagnosis established by majority opinion. Web based
e-pathology resources based in the Cleveland Clinic e-pathology center will be utilized by the Pathology Core
to facilitate central review in a cost efficient manner. Routine sections and immunohistochemical stains will be
scanned using an Aperio whole slide imaging system, and reviewing pathologists will be provided access to
review their assigned cases through a web based interface. Aim 2) To complete ancillary studies as required
to reach a final pathologic diagnosis. Additional ancillary testing may include immunohistochemical stains,
fluorescence in situ hybridization (FISH) studies and/or lymphoid clonality testing, may be necessary in some
cases to arrive at a definitive consensus diagnosis. Such testing, when requested by the pathologists
performing central review, will be performed in the Cleveland Clinic research core laboratories which include 1
Ventana Discovery, 3 Ventana Benchmark XT, 2 Ventana Benchmark Ultra, and 1 Dako
immunohistochemistry platforms. An extensive FISH menu and PCR clonality assays employing gold standard
Euroclonality primer sets are also available. Aim 3) To facilitate individual research projects through
construction of tissue microarrays. Tissue microarrays will be constructed from samples submitted for Projects
2 and 3. Dr. James Cook will serve as PI for the Pathology Core. Dr. Cook has extensive experience in
central pathology review for multi-institutional studies, having been a member of the LLMPP lymphoma
pathology committee and the SWOG lymphoma pathology committee since 2005. Dr. Cook is supported by a
strong Research core group within the Cleveland Clinic Pathology and Laboratory Medicine Institute, including
research technologists, project managers, accounting experts, and other administrative support. This Core will
impact each of the Projects 1-4 in this grant by ensuring each case studied has been thoroughly vetted and
providing a gold standard, consensus pathologic diagnosis

## Key facts

- **NIH application ID:** 10237166
- **Project number:** 5P01CA229100-04
- **Recipient organization:** MAYO CLINIC ARIZONA
- **Principal Investigator:** James R Cook
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $134,736
- **Award type:** 5
- **Project period:** 2018-09-19 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10237166

## Citation

> US National Institutes of Health, RePORTER application 10237166, Pathology Core (5P01CA229100-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10237166. Licensed CC0.

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