Treating Stimulant Addiction with Repetitive Transcranial Magnetic Stimulation

NIH RePORTER · VA · I21 · · view on reporter.nih.gov ↗

Abstract

Stimulant use disorder accounts for significant disability and dysfunction among Veterans. We currently do not have effective somatic treatments for this condition. This proposal will conduct a feasibility study to determine our ability to administer and complete a double-blind, sham-controlled randomized study using repetitive transcranial stimulation (rTMS) for treating stimulant use disorder. Half of the participants will be randomly assigned to receive sham treatment and the other half to receive active rTMS to the dorsolateral prefrontal cortex (DLPFC). We will also obtain pilot data supporting the efficacy of rTMS on reducing relapse rates and improving psychosocial functioning. And lastly, we will complete an exploratory aim in which we will obtain pilot data on the ability of fMRI scans to yield biomarkers that will be useful in selecting which Veterans would most benefit from intensive interventions such as rTMS

Key facts

NIH application ID
10237180
Project number
5I21RX003314-02
Recipient
VETERANS ADMIN PALO ALTO HEALTH CARE SYS
Principal Investigator
JONG H YOON
Activity code
I21
Funding institute
VA
Fiscal year
2021
Award amount
Award type
5
Project period
2020-09-01 → 2023-04-30