# Administrative Supplement to Gastroparesis Consortium

> **NIH NIH U01** · TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO · 2020 · $147,930

## Abstract

Project Summary/Abstract:
This administrative supplement follows strategy for parent grant 5U01DK074035-12
Gastroparesis (GP) presents with chronic upper GI dysmotility symptoms in the setting of delayed gastric
emptying without any mechanical obstruction. Inconsistencies exist between subjective symptom severity and
objective evidence of GP, while the availabilities of therapeutic options are very limited. Hence the
pathophysiology, clinical course, outcomes and treatment strategies require further investigation. Our response
to the NIDDK Gastroparesis Consortium (U01) under RFA-DK-16-010 has the following aims: 1) To complete
approved studies initiated by the GpCRC which entails enrolling GP patients to Gastroparesis Registry 3 with
their clinical data and bio-samples as well as obtain gastric tissue under the pathological basis of gastroparesis
(PBG) protocol, when some patients undergo surgery for failed medical therapy. This data collection will
contribute more knowledge about pathogenesis, pathomorphology, symptoms severity grading, complications,
and treatment outcomes in patients with GP as well as gastroparesis-like presentation but normal gastric
emptying. 2) We plan to continue our very successful enrollment of patients qualified for the BESST study
(Buspirone for Early Satiety and Symptoms of Gastroparesis: A Multicenter, Randomized, Placebo-Controlled,
Double-Masked Trial. 3) It is also our goal to initiate a very innovating, challenging and interesting study titled:
Pyloric Sphincter Abnormalities in Patients with Gastroparesis (PSAGS). The objective of this study is to
determine any potential pyloric sphincter abnormalities in GP patients when compared with healthy controls.
We aim to determine how prevalent these abnormalities are by using three tests : a) measure pyloric sphincter
diameter, cross-sectional area, pressure, compliance, and distensibility using endoluminal functional luminal
imaging probe (EndoFLIP™) technology; b) assess the regularity and a strength of stomach gastric slow
waves and accommodation status by electrogastrography (EGG) with water load satiety testing (WLST) and;
c) obtain recordings of gastric emptying, small bowel transit time (SBTT), and colon transit time (CTT)
captured by wireless motility capsule (WMC). In addition as a new diagnostic strategy, we propose to
determine whether endoscopy guided core biopsy samples of antral muscularis propria in GP patients can
provide sufficient tissue for full histologic analysis to specifically address status of interstitial cell of Cajal,
myenteric plexus neurons and smooth muscle pathology. Therefore we will investigate whether this
endoscopic method can safely replace surgically obtained gastric smooth muscle tissue and correlate ICC
findings with symptoms, gastric emptying and treatment outcome. This information is crucial in order to be able
to provide pathophysiological analysis in patients with mild to moderate GP symptoms, who did not reach a
severe enou...

## Key facts

- **NIH application ID:** 10237580
- **Project number:** 3U01DK074035-12S1
- **Recipient organization:** TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO
- **Principal Investigator:** Richard Warwick McCallum
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $147,930
- **Award type:** 3
- **Project period:** 2008-09-30 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10237580

## Citation

> US National Institutes of Health, RePORTER application 10237580, Administrative Supplement to Gastroparesis Consortium (3U01DK074035-12S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10237580. Licensed CC0.

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