Genomics and Bioinformatics Core (GBC): PROJECT SUMMARY/ABSTRACT The Genomics and Bioinformatics Core (GBC) delivers cost-effective analytical genomics solutions and bioinformatics analyses for intellectual and developmental disabilities (IDD) researchers. The objective of the GBC is to maximize the potential for researchers to develop new insights, diagnostics and therapeutic interventions for individuals with IDD by removing obstacles for leveraging genomic methods. The GBC has a dedicated staff led by internationally known investigators with an established track record in multidisciplinary research with a focus in genomics and bioinformatics. The genomics group of the Core provides equipment, expertise and training to support efficient utilization of genomics technologies. The bioinformatics group develops computational tools for omics data, designs best practices for utilizing large datasets, and provides training in biomedical data sciences. Advances in genome sequencing technologies enable researchers to identify changes that relate to IDD. The aims of the GBC are to provide access to, and training in, cutting edge techniques and technologies that can result in insights into the genetic basis of IDDs, to capture high resolution single cell level data of gene expression that contribute to development and dysregulation in IDDS and to maximize the impact of genomic information in understanding IDD by integrating genomic data with clinical, behavioral and pathophysical knowledge. In this way, the GBC will contribute to the understanding of the molecular physiology of IDDs and create new opportunities to develop diagnostics and therapeutic interventions.