# Mouse Genetics Core

> **NIH NIH U19** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $322,334

## Abstract

Abstract
Mouse models provide highly tractable models with which to assess, identify and mechanistically characterize
the role of genetic variants on infectious disease responses. The Mouse Genetics Core has been at the
forefront of designing experimental crosses, sequence datasets and other mouse resources with which to
investigate and perturb polymorphic immune networks. Following the identification of polymorphic host
genome regions, aberrant mouse lines, and discordant immune spreads or candidate genes and pathways
from human studies (in close collaboration with the Projects and the Systems Genetics and Bioinformatics
core), we will generate a variety of mouse experimental models for the Projects to further assess, identify and
characterize these processes. These models will include F1 panels contrasting variant disease alleles, F2
mapping populations, and mouse strains with modified candidate genes. Concurrently, designing the
appropriate experiments for the study of viral disease requires an understanding of the underlying immune
composition of individuals. Therefore, the Core will identify and further characterize genetic variants impacting
basal immune responses; both intra-cellular as well as at the whole-organism level. These data will be
provided to the projects to enhance their assessment of antiviral and/or perturbed response.

## Key facts

- **NIH application ID:** 10238907
- **Project number:** 5U19AI100625-10
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Fernando Pardo-Manuel de Villena
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $322,334
- **Award type:** 5
- **Project period:** 2012-08-05 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10238907

## Citation

> US National Institutes of Health, RePORTER application 10238907, Mouse Genetics Core (5U19AI100625-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10238907. Licensed CC0.

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