# Center for Adaptive Neurotechnologies

> **NIH NIH P41** · ALBANY RESEARCH INSTITUTE, INC. · 2021 · $1,086,037

## Abstract

NCAN Summary
Engineers and scientists at the National Center for Adaptive Neurotechnologies (NCAN) are creating technologies
that can guide CNS plasticity to enhance recovery for people with spinal cord injury, stroke, or other neuromuscular
disorders. NCAN is producing new insights and novel therapies and disseminating them to engineers, scientists,
and clinicians everywhere. This renewal application proposes to enhance NCAN technologies, apply them to
critical problems, hasten their clinical translation, and increase their wider impact.
Aim 1 will develop a wholly implanted wireless system for long-term 24/7 interactive studies in freely moving
rats. It will use this new system for the first study of the molecular biology underlying spinal reflex operant
conditioning, a promising new therapy that can enhance recovery after spinal cord injury or other disorders. This
novel system will support many kinds of long-term real-time interactive interventions for NCAN and for other
researchers. Aim 2 will develop a robust clinical system that supports a wide variety of protocols designed to
target beneficial plasticity to key CNS sites and is suitable for widespread clinical use. It will optimize this new
system in collaboration with clinical therapists and provide it for therapeutic studies focused on spinal cord injury,
cerebral palsy, and stroke. Aim 3 will develop a clinically practical system that uses electrical stimulation via
electrocorticographic/stereoencephalographic electrodes to map brain networks, define causality between areas,
and ultimately, to target plasticity that restores function impaired by stroke or other disorders. It will thereby create
a new imaging modality that can reveal point-to-point functional connections in the brain, relate them to behavior,
and enable their therapeutic modulation. Aim 4 will provide training in and promote dissemination of NCAN
neurotechnologies. It will enhance NCAN's 3-week short course curriculum, continue to offer many topic-specific
workshops in appropriate venues, and provide materials and guidance that enable other institutions to create their
own topic-specific courses. It will disseminate and support training materials and technologies through the NCAN
website and other mechanisms. Aim 5 comprises the administration that supports all NCAN activities.
This new grant period will include further development of major successes of the first grant period, initiation of
new technologies and novel therapeutic protocols, strong synergistic interactions among the Aims, intensive
collaborations with industry, and growing focus on clinical translation of NCAN technologies and protocols.
In summary, NCAN will continue to create novel neurotechnologies, define their mechanisms, translate them into
widespread use, and provide training and dissemination that enable and encourage other scientists, engineers,
and clinicians to join in developing these technologies and applying them to major scientific and clin...

## Key facts

- **NIH application ID:** 10239062
- **Project number:** 5P41EB018783-08
- **Recipient organization:** ALBANY RESEARCH INSTITUTE, INC.
- **Principal Investigator:** Jonathan Rickel Wolpaw
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,086,037
- **Award type:** 5
- **Project period:** 2014-09-10 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10239062

## Citation

> US National Institutes of Health, RePORTER application 10239062, Center for Adaptive Neurotechnologies (5P41EB018783-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10239062. Licensed CC0.

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