# Metabolomics Shared Resource

> **NIH NIH P30** · BAYLOR COLLEGE OF MEDICINE · 2021 · $96,649

## Abstract

PROJECT SUMMARY: Metabolomics Shared Resource (MSR)
The Metabolomics Shared Resource (MSR) is evolving to fulfill the research needs and mission of the Dan L
Duncan Comprehensive Cancer Center (DLDCCC). This Shared Resource (SR) provides advanced mass
spectrometry approaches and technologies, scientific consultation, and expert data analytics as is required for
high quality global and targeted metabolomics studies. The MSR specializes in discovery, identification,
characterization, and quantification of biomolecules, as well as metabolic flux analysis, from a variety of
biological specimens including tissues, cell lines, and fluids. The main infrastructure of the MSR consists of 5
high-end mass spectrometry systems and upfront liquid chromatography columns that are most suitable for
covering the range of metabolomic analyses developed as services including an Agilent 6490 Triple Quad
Mass Spectrometer, 2 Agilent 6495 Triple Quad Mass Spectrometers, an Agilent 6550 Time of Flight Mass
Spectrometer, and a SCIEX Triple TOF mass spectrometer with Schimadzu Nexera UHPLC-System with data-
independent acquisition for lipidomics. The MSR has a dedicated team of experts in mass spectrometry with
extensive experience in metabolomic profiling and biological expertise in cellular metabolism and data
analysis. Metabolomics became a Shared Resource of the Cancer Center for the first time at the last
competing renewal of the CCSG in 2015. Since then, the MSR has supported a broad range of DLDCCC
members across 6 of the 7 Programs and a total of 57 publications, many representing major projects in high-
impact journals including Nature, Journal of Clinical Investigations, Nature Communications, PLoS Genetics,
Nature Metabolism, Cell Reports, Cancer Cell, Cancer Research, and Clinical Cancer Research. This is a
dynamic SR facility that has kept pace with rapidly emerging technologies and instrumentation and has been a
leader in the field by developing and publishing innovative technologies. The MSR has developed state-of-the-
art technologies as core support services that includes the following: (1) Steady-state targeted metabolomics
with a capacity for quantification of up to 700 known metabolites; (2) Untargeted metabolomics for identification
of up to 1200 metabolites; (3) Lipidomics for up to 800 molecules and; (4) Metabolic flux analysis to monitor
changes in activities of major metabolic pathways in experimental model systems. The MSR, as proposed in
this application, can bridge the gap in our understanding of molecular pathways involved in cancer biology and
enable a wide range of DLDCCC research groups to explore the role of metabolism in cancer utilizing cutting-
edge technologies with quality, efficiency, and accuracy which would not be possible otherwise.

## Key facts

- **NIH application ID:** 10239123
- **Project number:** 5P30CA125123-15
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Nagireddy Putluri
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $96,649
- **Award type:** 5
- **Project period:** 2007-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10239123

## Citation

> US National Institutes of Health, RePORTER application 10239123, Metabolomics Shared Resource (5P30CA125123-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10239123. Licensed CC0.

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