# Developmental Funds

> **NIH NIH P30** · BAYLOR COLLEGE OF MEDICINE · 2021 · $401,062

## Abstract

DEVELOPMENTAL FUNDS
PROJECT SUMMARY:
In the last 5-year cycle, the Dan L Duncan Comprehensive Cancer Center (DLDCCC) leveraged CCSG
Development Funds ($300K) with more than $1.1M in Director's Discretionary Funds to fund 28 Pilot Projects
from 2015 to 2019. The Executive Committee (EC) targeted the RFAs for these awards to meet DLDCCC
strategic plan goals, including promoting high priority areas of research, fostering inter-programmatic
collaborations, and addressing the cancer burden of our Catchment Area. The 28 projects garnered a 9.5 fold
return on investment based on new grant support arising from the scientific pilot projects. The EC also used
institutional funds to develop a new PDX shared resource. In addition, with the discontinuation of the Early Phase
Clinical Research mechanism during this past funding period, the Center requested that those funds ($100k) be
repurposed to provide protected time for young clinical investigators to develop their research programs. Early
metrics from this strategy are promising with the first recipient, Brandon Smaglo, opening two investigator-
initiated trials that have accrued 30 patients. The current recipient, Daniel Wang from the Mechanisms in Cancer
Evolution Program, is developing studies to validate a microbiome signature in recipients of checkpoint inhibitors
and genetically modified T cells. He also created the Immunotherapy Toxicity Working Group.
In the next 5 years, the DLDCCC is requesting an increase in the Developmental Funds budget to $450K/year.
Developmental Funds in this renewal are being requested for two purposes: 1) $250k/year to enhance an
effective and successful Pilot Project program, and 2) $200K/year to expand support of junior clinical
investigators – which has been identified both nationally and in the DLDCCC strategic plan as an important
priority for NCI cancer centers.

## Key facts

- **NIH application ID:** 10239134
- **Project number:** 5P30CA125123-15
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** C KENT OSBORNE
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $401,062
- **Award type:** 5
- **Project period:** 2007-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10239134

## Citation

> US National Institutes of Health, RePORTER application 10239134, Developmental Funds (5P30CA125123-15). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10239134. Licensed CC0.

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