# Animal Behavior and Physiology Core (AB&P)

> **NIH NIH P50** · BOSTON CHILDREN'S HOSPITAL · 2021 · $285,215

## Abstract

ABSTRACT
The mission of the Animal Behavior and Physiology (AB&P) Core is to enable deep animal model
phenotyping and early-phase CNS drug and gene therapy discovery by providing cutting-edge behavioral
and physiological assays and related scientific expertise to the IDD research community. In line with the
mission, the AB&P Core is therefore designed to synergize cutting-edge behavior and in vivo physiology
analysis. As a facility focused on in vivo IDD models, the AB&P Core will provide unified services to IDDRC
investigators at the interface between the molecular/cellular and clinical/translational IDDRC components.
The Core enables (1) the standardization and validation of experimental procedures with appropriate rigor
and reproducibility, (2) quantitative and in-depth mammalian IDD model phenotyping, and (3) the
development of translational biomarkers, particularly for purposes of detecting target engagement by
experimental therapeutics. The integration of behavioral endpoints with quantitative physiological
biomarkers provides a means for assessing both preclinical proof of concept and clinical trial readiness of
proposed IDD treatments. As new technologies become available, the Core rapidly introduces them into its
tool portfolio and makes them available to Core users. In addition to providing the experimental platforms,
the Core provides deep expertise in in vivo experimental design, signal analysis and overall study
interpretation.

## Key facts

- **NIH application ID:** 10239468
- **Project number:** 1P50HD105351-01
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** Michela Fagiolini
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $285,215
- **Award type:** 1
- **Project period:** 2021-07-22 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10239468

## Citation

> US National Institutes of Health, RePORTER application 10239468, Animal Behavior and Physiology Core (AB&P) (1P50HD105351-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10239468. Licensed CC0.

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