# Control of polio virus fecal shedding (transmission) following a mucosally-adjuvanted fractional dose inactivated polio vaccine

> **NIH NIH P20** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2020 · $239,566

## Abstract

Paralytic Polio is a devastating cause of flaccid paralysis and its eradication is a major initiative of the 
World Health Organization (WHO). The addition of a mucosal adjuvant to intradermal (ID) IPV 
formulations may arrest fecal shedding and halt perpetuation of an environmental reservoir of the disease. 
We will evaluate the mucosal and cell mediated immune effects of a novel mucosal adjuvant: 
Enterotoxigenic Escherichia coli (ETEC), double-mutant heat labile toxin (dmLT). In addition, we will 
investigate the role of the gastrointestinal microbiota in modulating OPV-induced PV infection and 
replication capacity. In year 1, clinical samples immediately available from a completed pilot trail 
evaluating the safety and immunogenicity of dmLT-fIPV (CHRMS# 19-0048) will be utilized to develop 
methods and initiate immunologic investigations. During this time, regulatory and administrative work will 
be finalized to support the initiation of a second clinical trail in year 2.

## Key facts

- **NIH application ID:** 10239593
- **Project number:** 5P20GM125498-03
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Jessica W. Crothers
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $239,566
- **Award type:** 5
- **Project period:** 2020-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10239593

## Citation

> US National Institutes of Health, RePORTER application 10239593, Control of polio virus fecal shedding (transmission) following a mucosally-adjuvanted fractional dose inactivated polio vaccine (5P20GM125498-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10239593. Licensed CC0.

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