(CORE C- BDSC: BIOSTATISTICS & DATA SCIENCE CORE) PROJECT SUMMARY Description: The Biostatistics & Data Science Core (BDSC) provides comprehensive and expert analytic tools for IDDRC users desiring support in quantitative experimental design, biostatistics, and informatics techniques with particular emphasis on machine learning. The Core has substantive expertise in areas represented by two sub-cores (1) Biostatistics, with faculty from the Department of Biostatistics, Epidemiology & Informatics at the University of Pennsylvania (PENN) supporting experimental design of basic science, clinical trials and observational studies and the analysis of the ensuing data (2) Informatics and machine learning, with faculty from the Department of Biomedical Health Informatics at Children’s Hospital of Philadelphia (CHOP), providing support for high-level data integration of ‘omics’ data along with interpretation, classification and predictive modelling. A third sub-core will support Career Development and Education. Core members are committed mentors and teachers. Dr. Mary Putt, Professor of Biostatistics and former Associate Vice-Chair of the Graduate Group in Epidemiology & Biostatistics and Program Chair of the Biostatistics graduate program, is the overall Core Director and Director of the Biostatistics Sub-Core. Dr. Kai Wang, Associate Professor of Biomedical Health Informatics at CHOP and Pathology (PENN) and, and Senior Fellow of the Institute for Biomedical Informatics, is Associate Director of the Informatics & Machine Learning Sub-Core. Dr. Rui Xiao, Associate Professor of Biostatistics, and Pediatrics, is Associate Director of the Career Development & Education Sub- Core Relevance to IDDRC Mission: The BDSC supports the overall themes of our IDDRC, specifically (1) impactful research into the cause and treatment of conditions related to intellectual and developmental disability (IDD) and (2) career development and education of a new generation of IDD researchers. The BDSC evolved out of the previous Biostatistics & Bioinformatics core; it interacts with and/or complements the activities of the other IDDRC Cores as well as the Research Project. The Biostatistics faculty (Drs. Putt and Xiao) from this well-established core have joined forces with colleague, Dr. Kai Wang, expert in Informatics and Machine Learning to form the new Biostatistics & Data Science core. The Biostatistics faculty, through long association with the IDDRC, are integrated into multiple domains of IDD biomedical research, from basic science to clinical and translational medicine. Dr. Wang, through his expertise in machine learning and other informatics approaches, his recently established collaborations with IDDRC members and extensive experience in brain disorders, adds a new and exciting angle to the new generation of big data analytics and training. Eligibility: These services are available both to approved users of the IDDRC at Children’s Hospital of Philadelphia/University ...