# New Approaches to Dementia Heterogeneity

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $315,000

## Abstract

ABSTRACT
The UCSF Alzheimer’s Disease Research Center (ADRC) is a major catalyst for a broad spectrum of
dementia-related research conducted at UCSF and has served as a cornerstone for national and international
multi-site diagnostic and treatment studies. In three previous cycles of funding under the P50 mechanism, we
have organized a critical mass of dementia research and share our resources widely. We excel in clinical
phenotyping, imaging, biospecimen collection, and pathologic evaluation of large and unique cohorts of early-
onset AD (EOAD), frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), corticobasal
syndrome (CBS), Creutzfeldt-Jakob disease (CJD), and healthy controls. The ADRC supports and effectively
leverages additional NIH and foundation funding, philanthropy, and industry collaborations to accomplish its
aims. At the UCSF Memory and Aging Center alone, ADRC clinical cohorts, data, and biosamples are currently
utilized by 26 R grants, 6 K awards, 4 U grants, and 38 non-NIH grants. Projects and pilot awards have helped
launch young investigator careers and major research programs. ADRC data and biosamples are utilized
extensively by other ADRCs and an extensive network of collaborators.
 In this new P30 application, we accelerate efforts to define subtypes of healthy aging, MCI, AD, FTD, PSP,
CBS, and CJD that predict specific molecular and physiological causes for dementia, improve early recognition
and tracking of transitions from normal aging to dementia, and stimulate drug development and clinical trials.
The ADRC will consist of seven cores: Administrative, Clinical, Data Management and Statistics, Pathology,
Outreach Recruitment and Engagement, Imaging, and Biomarker and a Research Education Component. These
cores will work collectively to pursue the following overarching specific aims: Aim 1: Explore the heterogeneous
features of healthy aging, MCI, AD, FTD-spectrum disorders, and CJD to better understand their clinical, genetic,
and molecular underpinnings. Aim 2: Leverage the valuable cohorts in the ADRC and the talented neuroscience
communities at UCSF and beyond to “enhance the performance of innovative research” around diagnosis and
treatment of dementia. Aim 3: Increase understanding of the unique cultural and biological features of aging
Chinese and Latino Americans, while educating these communities with outreach lectures and web-based
presentations. Aim 4: Develop innovative approaches to data management and biostatistics to support easy
access and analysis of ADRC-related data while offering statistical support to our investigators. Aim 5: Train
new leaders in dementia research with innovative education approaches and educate medical and lay
communities about the heterogeneity of dementia with conferences, web-based presentations, and films.
Aim 6: Create a new Biomarker Core to enhance the genomic, proteomic, and transcriptomic data captured from
our extensive biospecimen collection. Aim 7: Transit...

## Key facts

- **NIH application ID:** 10240355
- **Project number:** 3P30AG062422-02S4
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** BRUCE L MILLER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $315,000
- **Award type:** 3
- **Project period:** 2019-05-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240355

## Citation

> US National Institutes of Health, RePORTER application 10240355, New Approaches to Dementia Heterogeneity (3P30AG062422-02S4). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10240355. Licensed CC0.

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