# Inflammatory Bowel Disease Genetics Consortium Data Coordinating Center

> **NIH NIH U24** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $1,452,414

## Abstract

PROJECT SUMMARY/ABSTRACT
This proposal is submitted in response to RFA-DK-16-510, “Limited Competition for the Data Coordinating
Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)”. IBD affects
1.8 to 3 million Americans; better therapies and more rational use of multiple emerging therapies are urgently
needed. Over 200 loci have been associated to IBD, prioritizing cells, genes and pathways that drive
pathogenesis. The IBDGC, comprised of the DCC and six Genetic Research Centers (GRCs) throughout North
America brings together large IBD referral centers to perform well-powered genetic, expression and functional
studies. Novel protocols for intestinal sampling and longitudinal follow-up are needed to define precise cellular
and molecular mechanisms. In Aim 1, the DCC will apply new laboratory and computing technologies to collect
accurate, detailed data on disease pathogenesis from the clinic all the way down to the cellular level, and to
integrate these data with both existing and new genomic data for sharing with the research community.
Platforms for longitudinal collections, integration with top collaborating laboratories, and development of new
objective assessments of disease activity and responses to treatment are described. The Bionimbus Protected
Data Cloud will facilitate collaborative analyses, and data sharing will be enhanced through an IBD Data
Commons. In Aim 2, prioritization of scientific directions and incorporation of new technologies, sampling
strategies and analyses is proposed. Key factors include efficiently scaling processes across centers,
minimizing and defining analytic and other sources of variation, and longitudinal analyses. Enhancement of
credible SNP set definitions will be achieved through increasing power through increased sample sizes of
genome-wide association study SNP sets, combining analyses across inflammatory diseases, and integrating
more diverse populations. Comprehensive expression analyses of a spheroid collection of inflamed and
uninflamed samples derived from ulcerative colitis (UC) patients will define mRNA expression variation driven
by genetic variability, thereby defining drivers of UC pathogenesis. Finally, in a large cohort of Crohn's disease
patients undergoing ileal resectional surgery, the genetic basis for how pathophysiologic mechanisms function
over time will be defined. This large sample set will enable the examination of genetic variation in response to
therapeutic interventions and over time. The long-term goal of these studies is to efficiently develop
approaches to most effectively treat IBD patients, catalyzing the advent of Precision IBD.

## Key facts

- **NIH application ID:** 10240466
- **Project number:** 5U24DK062429-22
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** JUDY H. CHO
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,452,414
- **Award type:** 5
- **Project period:** 2002-09-30 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240466

## Citation

> US National Institutes of Health, RePORTER application 10240466, Inflammatory Bowel Disease Genetics Consortium Data Coordinating Center (5U24DK062429-22). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10240466. Licensed CC0.

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