# Clinical Characterization Core

> **NIH NIH P50** · YALE UNIVERSITY · 2021 · $466,647

## Abstract

SUMMARY
The Clinical Characterization Core (CC Core) has been carefully designed to support the science proposed in
the five individual Projects while also advancing the ACE Center’s integrative mission: utilizing interdisciplinary
approaches to answer critical questions about underlying mechanisms and biological pathways implicated in
the expression of ASD-related symptoms across developmental epochs spanning fetal and neonatal, infant
and toddler, as well as school aged periods. The overarching purpose of the CC Core is to provide the
recruitment and scheduling infrastructure across all five ACE Projects, as well as comprehensive clinical
characterization for all participants. The CC core draws on a highly trained group of clinicians and support staff
who have extensive knowledge and long-standing experience working with individuals with ASD and their
families. Centralizing the recruitment, scheduling, and clinical characterization efforts across Projects will
ensure cost effectiveness, while capitalizing on expert clinical and technical skills. The CC Core will perform,
assist, train, and support the implementation of a comprehensive set of characterization procedures. Moreover,
the CC Core will train both pre and post-doctoral fellows. Clinical staff will consult as well as assist Project
personnel in evidenced based strategies to use while working with children with ASD in order to increase the
success rate of participant completion during experimental procedures. The Core’s objectives include: (1)
supporting the various projects in executing highly complex daily operational and organizational tasks including
recruitment and scheduling; (2) promoting synergy across projects via facilitation of enrollment in all eligible
studies; (3) providing well-characterized cohorts of participants to the various project areas at the highest
possible level of expertise, validity, and reliability; (4) maintaining reliability and validity, as well as other
standards of clinical care, education, and training; (5) making available behavioral, diagnostic, and
psychometric expertise to all Core users; (6) making data readily available to other investigators and to comply
with NDAR requests. Via advancing these objectives, we will ensure cost effectiveness and quality control is
maximized.

## Key facts

- **NIH application ID:** 10240566
- **Project number:** 5P50MH115716-05
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Kelly Powell
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $466,647
- **Award type:** 5
- **Project period:** 2017-09-07 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240566

## Citation

> US National Institutes of Health, RePORTER application 10240566, Clinical Characterization Core (5P50MH115716-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10240566. Licensed CC0.

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