# P30 Core Grant for Vision Research

> **NIH NIH P30** · MASSACHUSETTS EYE AND EAR INFIRMARY · 2021 · $97,441

## Abstract

Project Summary – Functional Genomics Core
A critical step in the discovery of disease-related genes is demonstrating the functional effects of
putative disease-causing mutations. This is particularly challenging when the protein function is not
known or a role for the protein in ocular tissues has not previously been established. Zebrafish (Danio
rerio) are a cost-effective model organism to study functional effects of genomic variants. Zebrafish
have a number of advantages over other genetic systems for the study of human development and
disease and have been used to characterize the basis of many human genetic disorders. Compared
with mice, zebrafish husbandry, breeding and genetic manipulation are more efficient and less
expensive. The structure and function of the zebrafish eye is similar to humans and zebrafish have
been used as an important model organism for the study of genetic and environmental eye diseases
including those disorders investigated at the Massachusetts Eye and Ear (MEE). The purpose of the
Functional Genomics core is to provide expert assistance using zebrafish as a model system to
demonstrate functional effects of human disease-related gene variants and to model human inherited
ocular disorders. This is a new core that is addressing a critical need for functional genomics for the
vision investigators at MEE heavily engaged in disease gene discovery and characterization. The
core will provide zebrafish husbandry and will assist investigators with project planning including
morpholino design and design of guide RNAs for CRISPR/cas9 gene editing, training for zebrafish
embryo injection and other manipulations and characterization of genetically modified fish.

## Key facts

- **NIH application ID:** 10240749
- **Project number:** 5P30EY014104-18
- **Recipient organization:** MASSACHUSETTS EYE AND EAR INFIRMARY
- **Principal Investigator:** Kinga Bujakowska
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $97,441
- **Award type:** 5
- **Project period:** 2002-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240749

## Citation

> US National Institutes of Health, RePORTER application 10240749, P30 Core Grant for Vision Research (5P30EY014104-18). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10240749. Licensed CC0.

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