# Childhood Cancer Survivor Study

> **NIH NIH U24** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2020 · $1,410,782

## Abstract

ABSTRACT
The Childhood Cancer Survivor Study (CCSS) is a multi-institutional, multi-disciplinary collaborative research
resource established to systematically evaluate long-term outcomes among children diagnosed with cancer who
survived five or more years from diagnosis. With the recent successful expansion of the cohort to include
survivors diagnosed and treated over three decades (1970-1999), the CCSS is the world's largest established
open resource for survivorship research with 35,923 eligible survivors available for investigation of late mortality,
and 24,368 participants who have contributed health-related and quality of life outcomes. The resource includes
comprehensive annotation of treatment exposure, ongoing longitudinal follow-up and an established
biorepository, from which genotyping (SNP array) and sequencing (whole exome) of almost 6,000 survivors will
be available for investigators for identification of genetic susceptibility for disease- and treatment-induced late
effects. Extensive use by the research community has resulted in: 264 published or in press manuscripts now
cited over 12,600 times; 229 presented abstracts; 42 investigator-initiated grants, totaling $37.1 million in
funding; utilization by a diverse group of 673 investigators; training of 63 young investigators; conduct of six
randomized trials; increased knowledge to inform exposure-based clinical care guidelines; and a highly
successful model for multiple national and international collaborative initiatives of pediatric cancer survivorship
research. During the next five years, activities will focus on maintaining, enhancing and promoting use of this
singular resource. The overarching goal of the CCSS resource is to increase the conduct of innovative and high
impact research related to pediatric cancer survivorship.

## Key facts

- **NIH application ID:** 10240899
- **Project number:** 3U24CA055727-26S1
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Gregory Armstrong
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,410,782
- **Award type:** 3
- **Project period:** 1993-07-20 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240899

## Citation

> US National Institutes of Health, RePORTER application 10240899, Childhood Cancer Survivor Study (3U24CA055727-26S1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10240899. Licensed CC0.

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