# Innovation through collaboration at the intersection of childhood development and cancer: a platform for the Gabriella Miller Kids First Pediatric Data Resource Center

> **NIH NIH U2C** · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $400,000

## Abstract

Project Summary: Data Coordination Center
The Data Coordination Center (DCC) for the Gabriella Miller Kids First Pediatric Data Resource Center
(KFDRC) is tasked with analysis and harmonization of whole genome sequences and associated rich
phenotypic data across cancer and structural birth defect cohorts. The DCC team is comprised of subject
matter experts in pediatric disease, phenotypic harmonization, large-scale data coordination, software
development, genomic analyses, and management and providers of high-performance computational
resources. As approximately 6,000 genomic and phenotypic samples will be ready for analysis at the inception
of the project, the DCC's processing and annotation process will require a carefully defined but rapid response
to begin data analysis. As the data is being generated and submitted by multiple sites, the DCC will play a key
role in performing harmonization and ensuring data quality. To enable a quick standup of the harmonization
and analytical platforms, the DCC will establish an initial set of processes and best practices that will be
implemented by utilizing or expanding protocols used at existing Data Commons. As development of best
practices is an iterative process, and to ensure easy adoption of best practice changes as needed, the DCC
will work closely with the Data Portal team to employ data- and configuration-driven process development
principles. In this iterative fashion, the DCC will be able to continuously improve on workflow, analytics and
task processes to provide an efficient flow of high quality data to the KFDRC Data Portal for release to the
scientific community. During all phases of the KFDRC development, the DCC will have a deep commitment to
making sure all its systems enable data to be FAIR) for
interoperating as part of the NIH Commons. The DCC team will work with advisors and other teams in the
KFDRC project to deliver transparent, reproducible analytics/workflows, data dictionaries and best practices to
the pediatric research community.
findable, accessible, interoperable and reusable (

## Key facts

- **NIH application ID:** 10240946
- **Project number:** 3U2CHL138346-04S1
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** Deanne Marie Taylor
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $400,000
- **Award type:** 3
- **Project period:** 2017-06-25 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240946

## Citation

> US National Institutes of Health, RePORTER application 10240946, Innovation through collaboration at the intersection of childhood development and cancer: a platform for the Gabriella Miller Kids First Pediatric Data Resource Center (3U2CHL138346-04S1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10240946. Licensed CC0.

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