# EDAC: ENCODE Data Analysis Center

> **NIH NIH U24** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2021 · $1,975,273

## Abstract

PROJECT SUMMARY
The goal of the Encyclopedia of DNA Elements (ENCODE) project is to catalog all functional elements in the
human genome through the integration and analysis of high-throughput data. We propose to continue the
ENCODE Data Analysis Center (EDAC, DAC) which will provide support and leadership in analyzing and
integrating data from the ENCODE project as well as work closely with other ENCODE groups including the
Data Coordination Center. Our proposed DAC team (Zhiping Weng, Mark Gerstein, Manolis Kellis, Roderic
Guigo, Rafael Irizarry, X. Shirley Liu, Anshul Kundaje, and William Noble) has expertise across a wide range of
fields including transcriptional regulation, epigenetics, evolution, genomics and proteomics, regulatory RNA,
biophysics, and computational biology, where they are the leaders in machine learning, statistical genetics,
networks, and gene annotation. These investigators also have a history of successfully working collaboratively
in large consortia, particularly with other ENCODE groups. Their publication records demonstrate their
synergistic approach to producing high-impact science and useful resources that benefit the broader
biomedical communities.
The proposed DAC will pursue the following four aims: Aim 1. Analyze and integrate data and metadata from a
broad range of functional genomics projects; Aim 2. Serve as an informatics resource by supporting the
activities of the ENCODE Analysis Working Group; Aim 3. Create high-quality Encyclopedias of DNA elements
in the human and mouse genomes; Aim 4. Assess quality and utility of the ENCODE data and provide
feedback to NHGRI and the Consortium.

## Key facts

- **NIH application ID:** 10240955
- **Project number:** 3U24HG009446-04S1
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Mark Bender Gerstein
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,975,273
- **Award type:** 3
- **Project period:** 2021-02-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10240955

## Citation

> US National Institutes of Health, RePORTER application 10240955, EDAC: ENCODE Data Analysis Center (3U24HG009446-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10240955. Licensed CC0.

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