Project Abstract Parkinson’s disease (PD) is a growing global health problem that causes untold suffering for patients and their loved ones, and challenges health care systems. Motor symptoms are the classic features for which there are effective interventions; however, non-motor symptoms, especially cognitive impairment, are very common, may precede motor symptoms, and do not respond well to existing therapies. Solutions will come only from research. The Pacific Udall Center (PUC), one of nine NINDS-funded Morris K. Udall Centers of Excellence for Parkinson's Disease Research, is our response to this research imperative. PUC is committed to contributing to the long term, ambitious goal of developing the knowledge and tools for optimally targeted and timed interventions for cognitive impairment in PD. Our innovative three Cores and three Projects are structured around genetic risk for different types of cognitive impairment in PD. Our research focuses on molecular pathology and mechanisms of disease, investigation of neural systems using novel brain imaging, and mechanisms of balance and gait problems, in part an expression of cognitive impairment, in genetically-defined subgroups of patients with PD. Each of our research goals is ranked among the highest priority recommendations of two recent NINDS Conferences: Parkinson's Disease 2014: Advancing Research, Improving Lives and the 2013 Alzheimer's Disease-Related Dementias: Research Challenges and Opportunities (which included PD dementia).