# The Broad-LMM-Color Genome Center for All of Us

> **NIH NIH OT2** · BROAD INSTITUTE, INC. · 2020 · $70,224,476

## Abstract

The All of Us Research Program ( AoURP) requires a robust, accurate, and thoroughly CLIA
validated sample receipt process, with the capacity to process ~17,000 samples per month at high-quality.
To date, the Samples Lab has received, accessioned, and stored over 2 million samples (Figure 2) and has
been tested at scale with large national biobanks. To ensure high-quality at high-scale, our processes
leverage highly optimized automation with full LIMS tracking to ensure chain of custody and apply various
quality control (QC) assays on all incoming samples. We use the same process to receive samples for both
genotyping and sequencing. This streamlined approach—that is, performing genotyping and WGS in a single
CLIA lab environment—reduces the cost of cross-laboratory sample-identity checking, enables seamless
cross-validation of sequencing data with genotype data, and conserves material by allowing genotyping and
sequencing to be performed on a single aliquot of a participant’s sample.

## Key facts

- **NIH application ID:** 10241032
- **Project number:** 3OT2OD002750-01S2
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** Stacey Gabriel
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $70,224,476
- **Award type:** 3
- **Project period:** 2018-09-25 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241032

## Citation

> US National Institutes of Health, RePORTER application 10241032, The Broad-LMM-Color Genome Center for All of Us (3OT2OD002750-01S2). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10241032. Licensed CC0.

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