# PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOME

> **NIH NIH UM1** · STANFORD UNIVERSITY · 2021 · $3,168,080

## Abstract

ABSTRACT
Although our ability to determine the genome sequence of individuals is becoming facile, our understanding
of the function of most of the human genome is limited. Mapping of regulatory information is particularly
crucial since most (>85%) common variants associated with human disease lie outside of coding regions.
Previous phases of ENCODE have made important contributions to the mapping of regulatory elements
across the genome, but there is much more to be achieved, including the mapping of regulatory regions
across many more tissues and at the resolution of individual cells as well as determining the exact
regulators i.e. transcription factors that bind each region. In our Stanford ENCODE Production Center for
Mapping of Regulatory Regions, we plan to use technologies that we have developed to map the binding
sites for most transcription factors (TFs) in five major cell lines using chromatin immunoprecipitation of
tagged TFs. We will further expand the catalog of regulatory elements by analyzing open chromatin regions
in these cell lines and a wide variety of tissues and cell types from both normal and diseased human
subjects consented for open access. Finally, we will map open chromatin regions and expression in single
cells from these types of biosamples. These studies will greatly expand the catalog of regulatory regions in
the human genome. The rapid deposition of data into the ENCODE Data Coordinating Center (DCC) will
ensure quick public release. We expect the data and cell lines that are generated by this Center will be a
valuable resource for the broad scientific community.

## Key facts

- **NIH application ID:** 10241080
- **Project number:** 3UM1HG009442-04S1
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MICHAEL P. SNYDER
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $3,168,080
- **Award type:** 3
- **Project period:** 2021-02-01 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241080

## Citation

> US National Institutes of Health, RePORTER application 10241080, PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOME (3UM1HG009442-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10241080. Licensed CC0.

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