# Comprehensive linking of DNA Elements in high-priority ENCODE Biosamples to their promoter targets

> **NIH NIH UM1** · BAYLOR COLLEGE OF MEDICINE · 2021 · $947,579

## Abstract

ABSTRACT.
The roughly two meters of DNA in the human genome is intricately packaged to form the chromatin and
chromosomes in each cell nucleus. In addition to its structural role, this organization has critical regulatory
functions. In particular, the formation of loops in the human genome plays an essential role in regulating genes.
We recently demonstrated the ability to create reliable maps of these loops, using an in situ Hi-C method for
three-dimensional genome sequencing. Hi-C characterizes the three- dimensional configuration of the genome
by determining the frequency of physical contact between all pairs of loci, genome-wide. The proposed center
will apply Hi-C and other new technologies to characterize genomic loops, their regulation, and their functions.
We will specifically examine these structures in a wide variety of ENCODE cell types. The principles deduced
from our study will be applicable to any mammalian tissue type.

## Key facts

- **NIH application ID:** 10241100
- **Project number:** 3UM1HG009375-04S1
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Erez Lieberman-Aiden
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $947,579
- **Award type:** 3
- **Project period:** 2017-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241100

## Citation

> US National Institutes of Health, RePORTER application 10241100, Comprehensive linking of DNA Elements in high-priority ENCODE Biosamples to their promoter targets (3UM1HG009375-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10241100. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*