# ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive Sites

> **NIH NIH UM1** · ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES · 2021 · $3,086,945

## Abstract

ABSTRACT 
 
The  overall  mission  of  this  Mapping  Center  is  to  create  and  disseminate  open  access, 
comprehensive,  high-­quality,  high-­resolution  reference  maps  of  DNase  I  hypersensitive  sites 
(DHSs)  in  the  human  and  mouse  genomes,  at  previously  unattainable  levels  of  cellular  and 
anatomical  definition.  Regulatory  DNA  is  actuated  in  an  exceptionally  state-­specific  manner;; 
accordingly,  achieving  a  comprehensive  map  of  DHSs  necessitates  the  interrogation  of  an 
expansive  and  finely  partitioned  range  of  cell  and  tissue  samples.  Progressive  technical 
improvements  and  recent  innovations  have  resulted  in  dramatic  (>100x)  decreases  in  requisite 
input  biological  sample  quantities  coupled  with  equally  dramatic  (>100x)  increases  in  assay 
throughput, and corresponding decreases in the incremental cost of generating reference-­quality 
DHS maps.  These advances have in turn opened the possibility of systematically addressing all 
well-­defined  physiologically  and  disease-­relevant  anatomic  and  cellular  compartments.  Four 
major Specific Aims are targeted: (1) To create open access, comprehensive high-­quality, high-­
resolution reference maps of human DNase I hypersensitive sites;; (2) To create and disseminate 
comprehensive  high-­quality,  high-­resolution  reference  maps  of  mouse  DNase  I  hypersensitive 
sites;;  (3)  To  maintain  and  disseminate  reference  indices  of  DNase  I  hypersensitive  sites  and 
footprints in the human and mouse genomes;; and (4) To enable large-­scale intake of Consortium 
and Community samples for high-­quality, high-­throughput DHS mapping.

## Key facts

- **NIH application ID:** 10241208
- **Project number:** 3UM1HG009444-04S1
- **Recipient organization:** ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES
- **Principal Investigator:** JOHN A STAMATOYANNOPOULOS
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $3,086,945
- **Award type:** 3
- **Project period:** 2021-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241208

## Citation

> US National Institutes of Health, RePORTER application 10241208, ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive Sites (3UM1HG009444-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10241208. Licensed CC0.

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