# CHOP Pediatric Center of Excellence in Nephrology

> **NIH NIH P50** · CHILDREN'S HOSP OF PHILADELPHIA · 2021 · $835,054

## Abstract

CHOP PEDIATRIC CENTER OF EXCELLENCE IN NEPHROLOGY ABSTRACT
We propose to establish a Pediatric Center of Excellence in Nephrology (PCEN) at the
Children’s Hospital of Philadelphia (CHOP). Our theme is to address barriers to clinical trials
implementation in children with kidney disease. As kidney disease in children is uncommon,
identification of adequate numbers of children with specific disorders and recruitment for trials is
difficult. Additionally, methods to clinically phenotype children with kidney disease in terms of
growth, development, nutritional issues, cardiovascular disease risk factors, bone and mineral
disorders often vary from study to study, and quality control is variable. Expertise in study
design and analysis is needed to achieve appropriate inferences from observational data, and to
design clinical trials, however, frequently pediatric centers in nephrology lack this expertise. We
will address these challenges through a regional and national collaboration of clinical and
translational researchers at CHOP, Johns Hopkins, and children’s hospitals participating in
PEDSnet. PEDSnet is a consortium of eight academic pediatric health centers that collectively
provide care for >4.5 million children. PEDSnet has established a common institutional review
board and has harmonized the diverse EHR systems of its participating centers to create a
standardized multi-institutional data network in order to facilitate the efficient conduct of
observational research, quality improvement and clinical trials.
The CHOP-PCEN will have three biomedical research cores; a Design and Analysis core, a
Clinical Phenotyping Core focused on CVD risk factors and Nutrition/Bone health, a Learning
Health System (LHS) Core, as well as a pilot and feasibility program and an enrichment core.
We include 2 research project proposals utilizing the cores: “Bone Quality and Vascular Health
in Adolescents with Urinary Stone Disease”, “Derivation and Validation of Imaging Biomarkers
for CKD Progression” and a third, integrated into the LHS core, “Skeletal Outcomes in Children
and Young Adults with Glomerular Disease”. The research base is comprised of 39
investigators, who are PI’s, co-investigators or collaborators on over 150 funded projects
totaling over $35 million in annual direct costs, over $12 million of this funding is in research
projects relevant to pediatric nephrology led by likely users of the core services. The PCEN will
build upon the strong foundation of clinical research at CHOP and Hopkins, as well as the
University of Penn Adult Nephrology Division and Center for Clinical Epidemiology and
Biostatistics to catalyze the design and implementation of clinical trials in children with kidney
disease.

## Key facts

- **NIH application ID:** 10241465
- **Project number:** 5P50DK114786-05
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** SUSAN L. FURTH
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $835,054
- **Award type:** 5
- **Project period:** 2017-09-18 → 2022-09-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241465

## Citation

> US National Institutes of Health, RePORTER application 10241465, CHOP Pediatric Center of Excellence in Nephrology (5P50DK114786-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10241465. Licensed CC0.

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