# Molecular Mechanisms of Environmental Injury

> **NIH NIH T32** · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $90,317

## Abstract

PROJECT SUMMARY/ABSTRACT
The UTMB Environmental Toxicology T32 Training Grant has been in existence at UTMB since 1990. In the
over 20 years of its existence, training has been provided to over 70 predoctoral fellows and 28 postdoctoral
fellows, including 9 physician-scientists. The trainees who have completed their training have professional
positions in basic research, biotechnology, teaching, risk assessment and/or practical problems of
environmental pollutant regulation and policy. Twelve have academic faculty appointments; three who
subsequently obtained law degrees are practicing environmental or patent law. A tangible outcome of our
policy about trainee submission of competitive research proposals is that 35 have obtained individual
fellowships, including 18 from NIEHS. Accordingly, we request support for 6 predoctoral fellows and 3
postdoctoral fellows per year, to continue this outstanding training program. Key elements in our unique
climate for training are a multiplicity of environmental-health relevant research centers and institutes, notably: 1)
the NIEHS Center in Environmental Toxicology (over 20 yr.), 2) the Institute for Translational Science (ITS) and
recently renewed (2015) NIH Clinical Translational Science Award (CTSA), 3) the Sealy Center for
Environmental Health and Medicine, 4) the recently renewed (2015) NIH Pepper Center on Aging, and 5) the
respective Sealy Centers for Molecular Science, Cancer Cell Biology, and Aging. We offer training in 4 areas
where we have critical masses of experienced faculty, exemplary institutional support, and superb resources
for state-of-the-art environmental and translational research. These areas are: 1) airway inflammation/
obstruction pathogenesis, 2) intracellular regulation and signaling, 3) DNA damage and repair, and 4) organ
pathophysiology, all with a unifying theme of oxidant injury. Training in airway inflammation/obstruction
pathogenesis is supported by 8 well-established trainers in 5 federally-funded asthma research programs;
training in intracellular regulation and signaling is a newer area, taking advantage of strengths within the ITS;
training in DNA damage and repair continues to grow and develop as previously, and training in organ
pathophysiology emphasizes our continued strong sub-areas of CNS toxicology, aging, and infection, providing
opportunities for toxicology training in translational sciences. Our didactic curriculum builds from an
interdisciplinary common first year, toward advanced courses in molecular toxicology, pathology,
proteomics/bioinformatics, and short courses on specialized topics. Identity and community within our training
program is established with structured activities such as toxicology courses and seminars, journal club, and
local, regional, and national toxicology meeting attendance. Professional development in teaching,
communication, mentoring, and academic responsibility is fostered by required participation in a new Principles
of Toxicology ...

## Key facts

- **NIH application ID:** 10241616
- **Project number:** 3T32ES007254-28S1
- **Recipient organization:** UNIVERSITY OF TEXAS MED BR GALVESTON
- **Principal Investigator:** BILL T AMEREDES
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $90,317
- **Award type:** 3
- **Project period:** 1990-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241616

## Citation

> US National Institutes of Health, RePORTER application 10241616, Molecular Mechanisms of Environmental Injury (3T32ES007254-28S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10241616. Licensed CC0.

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