# The role of adult-born dentate granule cells in influencing C3 neuronal activity

> **NIH NIH F30** · STATE UNIVERSITY NEW YORK STONY BROOK · 2021 · $51,036

## Abstract

Project Summary
 The hippocampus, a brain structure critical for learning and memory, is one of just two brain areas (along
with the olfactory bulb) that continue to add new neurons throughout adult life. The continual addition of new
neurons, known as adult neurogenesis, is disrupted in a variety of neuropsychiatric disorders, including major
depressive disorder, and post-traumatic stress disorder. While adult-born neurons are still immature, they
contribute to several learning and memory functions, including certain forms of spatial memory. The integration
of these new neurons into already existing circuits within the hippocampus appears to be necessary for healthy
hippocampal function, but the process by which these immature adult-born neurons affect activity in downstream
hippocampal regions is poorly understood.
 I have developed a novel anterograde labeling construct that will allow me to investigate the process, and
functional consequences of integration of adult-born neurons into already existent circuits. I have demonstrated
in my preliminary studies that I am able to label the anterograde synaptic connections with high fidelity. In this
proposal, I present two queries I intend to use my construct to pursue: (1) how activity (or lack of activity) of
adult-born hippocampal neurons affects downstream circuit activity in the hippocampus, and (2) whether neuro-
glial coupling is involved in mediating this effect. Understanding how adult-born neurons influence downstream
activity of already existent circuits is essential for developing new interventions for hippocampal disease, as well
as for normal age-related cognitive decline. Results from this study will allow for greater insight for the
development of new therapies for a variety of neuropsychiatric conditions.

## Key facts

- **NIH application ID:** 10241948
- **Project number:** 5F30MH116650-04
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Rachel Elizabeth Kery
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $51,036
- **Award type:** 5
- **Project period:** 2018-09-05 → 2022-09-04

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10241948

## Citation

> US National Institutes of Health, RePORTER application 10241948, The role of adult-born dentate granule cells in influencing C3 neuronal activity (5F30MH116650-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10241948. Licensed CC0.

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