# Development of phosphorylation-inducing chimeric small molecules

> **NIH NIH R21** · BROAD INSTITUTE, INC. · 2021 · $200,000

## Abstract

PROJECT SUMMARY
Protein phosphorylation can activate, inhibit, or modify protein’s function. Small molecules that block protein
phosphorylation via kinase inhibition exist, but methods to induce phosphorylation of any protein on demand
do not exist. We propose to develop a new class of small molecules, termed PHosphorylation Inducing Chimeric
Small molecules (PHICS), which will induce protein phosphorylation with dose and temporal control. PHICS
will be formed by joining a small-molecule kinase binder with a small-molecule binder of the target protein so
that an active kinase is brought into proximity to the target protein to initiate phosphorylation.
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## Key facts

- **NIH application ID:** 10242051
- **Project number:** 5R21AI154099-02
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** Amit Choudhary
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $200,000
- **Award type:** 5
- **Project period:** 2020-08-19 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10242051

## Citation

> US National Institutes of Health, RePORTER application 10242051, Development of phosphorylation-inducing chimeric small molecules (5R21AI154099-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10242051. Licensed CC0.

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