# Mouse Exercise and Metabolic Phenotyping Core

> **NIH NIH P01** · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $228,214

## Abstract

ABSTRACT
The Mouse Exercise and Metabolic Phenotyping Core (Core B) will facilitate the design and execution of
the exercise experiments for Program Project members. Core B leverages the facilities and infrastructure of an
original NIH-funded Mouse Metabolic Phenotyping Center (MMPC, www.mmpc.org) at Vanderbilt University
and the specific expertise of its Director, David Wasserman, PhD in exercise physiology. Core B has already
designed and executed exercise studies that have been recently published by the Elmquist, Zigman and
Williams laboratories, in addition to designing all of the exercise paradigms used to generate the respective
preliminary data for the current application. (see publications section within the individual projects).
Core B will provide the following Exercise Protocols and Measurements:
Exercise Protocols
 Incremental treadmill exercise test to assess peak O2 uptake and work capacity
 Analysis of endurance capacity utilizing motorized treadmills
 Perform acute high intensity interval exercise
 Perform chronic exercise training
Measurements
 O2 uptake, CO2 output, and respiratory exchange ratio (RER) will be measured during or after exercise
 Body mass and composition
 Blood sampling through an indwelling catheter
 Analysis of liver and skeletal muscle glycogen content
 Analysis of biochemical signaling pathways
 Analysis plasma analysis of insulin, ghrelin, glucagon, triglycerides (TG), and non-esterified fatty acids
(NEFA)

## Key facts

- **NIH application ID:** 10242069
- **Project number:** 5P01DK119130-03
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** DAVID H WASSERMAN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $228,214
- **Award type:** 5
- **Project period:** 2019-09-20 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10242069

## Citation

> US National Institutes of Health, RePORTER application 10242069, Mouse Exercise and Metabolic Phenotyping Core (5P01DK119130-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10242069. Licensed CC0.

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