# Pilot Projects and Trans-Network Activities

> **NIH NIH U54** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2021 · $179,182

## Abstract

Abstract 
This Pilot Projects Program (PPP) provides, after selection by external review and applicant discussion with 
senior UTPDTC investigators, a flexible and nimble platform for seed funding of novel research that has potential 
to significantly impact PDX and drug development research.We have the following Specific Aims: 1. Provide 
PPP funding to projects focused on PDX and drug development research. 2. Use the expertise of MDACC and 
UTSW scientific and clinical leaders and PDXNet investigators and Core leaders to identify high impact PDX 
and drug pilot projects in the UTMDACC, UTSW, PDXNet, and related environments. 3. Build on well- 
established mechanisms at UTMDACC and UTSW for mentorship of and integration with PDXNet investigators, 
Projects, and Cores. 4. Build on the existing PDXNet framework to promote communication between basic and 
clinical scientists, within and outside UTMDACC and UTSW, across disciplines, and guide the training of a new 
generation of PDX and drug development researchers. 5. Facilitate development and transition of these 
successful projects into competitive applications for peer-reviewed funding. 6. Build on existing PDXNet 
mechanisms to translate the findings into the clinic. Pilot Projects and Trans-Network Activities Core will interact 
with other Network units in the development of trans-Network collaborative projects, and will also assist non- 
Network investigators chosen to participate in PDXNet by NCI. Close interaction will be maintained with the 
PDCCC PDX Data Commons and Coordinating Center in terms of sharing data regarding PDX demographic 
information, molecular characterization and response to agents, and jointly developing methods to analyze data.

## Key facts

- **NIH application ID:** 10242645
- **Project number:** 5U54CA224065-04
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Jack Roth
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $179,182
- **Award type:** 5
- **Project period:** 2017-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10242645

## Citation

> US National Institutes of Health, RePORTER application 10242645, Pilot Projects and Trans-Network Activities (5U54CA224065-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10242645. Licensed CC0.

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